ArticleVeterinary medicine and science2025
Comparison of the Effectiveness of Nigella Sativa and Vitamin E in Preventing Intra-abdominal Adhesions.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Biological alternatives to chemical pleurodesis: Evaluation of autologous blood, platelet-rich plasma and platelet-rich fibrin in an experimental rat model.Turk gogus kalp damar cerrahisi dergisi · 2026Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the efficacy of locally applied Nigella sativa (NS) oil and Vitamin E (vit E) in a rat adhesion model. ANIMALS: Thirty-six male Wistar rats (90 days old, 240 ± 37 g)
methodsAnimals were assigned to three groups: control (sterile saline), NS oil (10 mg/kg), and vit E (50 mg/kg). After inducing intra-abdominal adhesion, the treatments were administered intraperitoneally. On day 8, rats were euthanized, and adhesions were scored macroscopically. Levels of IL-6, TNF-α, PGE2, TGF-β1, VEGF, IL-10 and IL-1β were measured, and histopathological evaluation and Picro-Sirius Red staining were performed.
resultsAdhesion scores did not significantly differ between groups (p = 0.680). TNF-α levels were significantly higher in the control group compared to the vit E group (p = 0.011), with no significant difference between the NS oil and vit E groups. PGE2 levels differed significantly between the NS oil and vit E groups (p = 0.023). IL-1β, IL-6, IL-10, TGF-β1 and VEGF levels did not show significant differences (p > 0.05). Histopathology revealed reduced fibrosis and inflammation in the vit E group compared to NS oil (p < 0.001). Picro-Sirius Red staining showed improved collagen maturation in the vit E group, followed by NS oil, with the control group exhibiting less mature collagen.
conclusionBoth treatments showed efficacy, but vit E was superior in reducing inflammation and fibrosis and enhancing collagen maturation.
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