Effect of β-blockade on measures and reproducibility of heart rate, oxygen uptake and work rate across repeated bouts of short-duration, RPE-regulated exercise.

Braden L Mitchell, Kade Davison, Gaynor Parfitt, Roger G Eston

Abstract read

In one paragraph

Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Measuring long-term physical activity in patients with heart failure and its relation to health-related outcomes.ESC heart failure · 2026
Observational

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Braden L MitchellAlliance for Research in Exercise Nutrition and Activity (ARENA), University of South Australia, Adelaide, SA, Australia. drblmitchell@gmail.com.ORCID http://orcid.org/0000-0002-8091-2549

Kade DavisonAlliance for Research in Exercise Nutrition and Activity (ARENA), University of South Australia, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-7101-7729

Gaynor ParfittAlliance for Research in Exercise Nutrition and Activity (ARENA), University of South Australia, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-5547-5797

Roger G EstonAlliance for Research in Exercise Nutrition and Activity (ARENA), University of South Australia, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-2680-7473

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe examined the effect of β-blockade on measures and reproducibility of heart rate (HR), oxygen uptake (

methodsParticipants completed an RPE-regulated, interval-based exercise session under control and β-blockade conditions with six 3-min bouts alternating between RPE 13 and RPE 15, separated by 2-min active recovery periods. Participants adjusted treadmill speed/grade to meet the target RPE. Linear mixed effects models assessed the effect β-blockade on exercise responses for each RPE, while intraclass correlation coefficients (ICC) and coefficients of variation (CV) evaluated reproducibility across bouts.

resultsβ-Blockade significantly reduced HR (- 36.5 beat min

conclusionOur findings suggest that despite significant reductions in absolute responses, β-blockade does not affect relative measures of

Indexed as

Adrenergic beta-AntagonistsExerciseHeart RateOxygen ConsumptionPhysical ExertionAdultExercise TestFemaleHumansMaleReproducibility of ResultsYoung AdultAdrenergic beta-AntagonistsBeta-blockadeExercise intensityInterval trainingPerceptually regulated exercisePerceptual regulationRating of perceived exertion

Identifiers

PMID40450656

DOI10.1007/s00421-025-05818-x

PMCPMC12528277

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.