Evidence map›Paper›PMID 40450623›Full record

ArticlePediatric surgery international2025

Postnatal outcomes of sonographically suspected isolated congenital lung anomalies.

Hanna Heinrich, Ingeborg H Linskens, Ramon R Gorter, Matthijs W N Oomen, Elisabeth van Leeuwen, Eva Pajkrt

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Article in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Hanna HeinrichDepartment of Obstetrics and Gynecology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. h.heinrich@amsterdamumc.nl.
Ingeborg H LinskensDepartment of Obstetrics and Gynecology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Ramon R GorterAmsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.
Matthijs W N OomenDepartment of Pediatric Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Elisabeth van LeeuwenDepartment of Obstetrics and Gynecology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Eva PajkrtDepartment of Obstetrics and Gynecology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim was to evaluate the prenatal course, postnatal outcome and diagnostic accuracy of fetuses with a prenatal diagnosis of isolated congenital lung anomalies (iCLA).

methodsA retrospective cohort is described from the Amsterdam UMC between January 2007 and January 2022. The CPAM volume ratio (CVR) was calculated. The concordance between prenatal diagnosis and lesion progression was compared to postnatal findings. Postnatal surgical interventions were reported.

resultsThis study includes 113 prenatal cases of iCLA. Ten percent (10/100 cases with available CVR) progressed into high-risk lesions (CVR > 1.6), with a negative impact on survival. In total, 108 (95.6%) cases resulted in live birth. Acute respiratory distress was observed in 6.5% (7/108). During postnatal follow-up, the lesion was still detectable in 10/15 (66.7%) cases in which complete regression was seen prenatally. Fifty percent (54/108) of the live-born children required surgical management. DISCUSSION: iCLA has a favorable prognosis in pregnancy, however, close prenatal monitoring is advised. Future parents should be informed about the importance of postnatal follow-up since lesions are often persistent even if prenatal scans may no longer have visualized them, as well as the chance of developing respiratory distress and the probability of undergoing surgery.

Indexed as

LungUltrasonography, PrenatalFemaleHumansInfant, NewbornMalePregnancyPrognosisRetrospective StudiesCongenital lung anomalyPregnancy outcomePrenatal diagnosis

Identifiers

PMID40450623
PMCPMC12127225

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