ArticleMedical science monitor : international medical journal of experimental and clinical research2025
An Enhanced Diagnostic Model for Incidental Hashimoto's Thyroiditis Using T2-Weighted and Diffusion-Weighted Imaging.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND The purpose of this study was to explore the diagnostic efficacy of the signal intensity ratio on T2-weighted imaging (T2WI) in conjunction with multi-b-value diffusion-weighted imaging (DWI) for the assessment of Hashimoto's thyroiditis (HT). MATERIAL AND METHODS A retrospective analysis was performed to evaluate the distinctions in T2WI-IDEAL water images and multi-b-value DWI parameters between 25 matched pairs of patients with and without Hashimoto's thyroiditis (HT). A combined diagnostic model for HT was subsequently developed. Additionally, the correlation between T2WI-IDEAL water images and multi-b-value DWI parameters and the levels of thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (Tg-Ab) was investigated. RESULTS The T/M, T/Tr, and T/L values of HT were higher than those of non-HT, while the ADC, D, and f values were lower than those of non-HT, with statistically significant differences (P<0.05). The combined diagnostic efficacy of T/M, T/Tr, and ADC for HT was optimal (AUC=0.94, sensitivity and specificity were both 92%). The T2WI-IDEAL water image and b-value DWI parameters were moderately or strongly correlated with TPO-Ab and Tg-Ab. CONCLUSIONS The T2WI grayscale ratio, ADC, and IVIM can, to a certain extent, quantitatively and objectively differentiate between HT and non-HT. By integrating T/M, T/Tr, and ADC, the ability to distinguish HT from non-HT can be enhanced, or they may function as a valuable imaging combination tool for diagnosing occasional HT.
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