ArticleJournal of cannabis research2025
Three-day delta-9-tetrahydrocannabinol (THC) exposure eliminates long-term depression in ventral tegmental area of young, but not adult mice.
Article in Journal of cannabis research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Evaluation of long-term safety profile of an EU-GMP certifiedFrontiers in pharmacology · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Ventral tegmental area (VTA) dopamine signaling plays a key role in reward learning and drug dependence. VTA dopamine cell activity is regulated in part by local GABA interneurons, which participate in regulating reward prediction. Previously, our lab identified a cannabinoid type 1 receptor (CB1)-dependent form of excitatory long-term depression (LTD) in VTA GABA cells. LTD was eliminated in both young and adult mice after 7-10-day delta-9-tetrahydrocannabinol (THC) exposure. To build off these previous findings, we used mouse ex vivo brain slices to examine whether young mice undergo THC-induced alterations to VTA GABA cell plasticity after fewer exposures than their adult counterparts, as human adolescents have increased sensitivity to THC. Whole-cell electrophysiological recordings were performed on young (P14-P54) and adult (P66-P240) mice treated with THC or vehicle control for 3 days, after which we attempted to induce CB1-dependent LTD ex vivo. Plasticity was eliminated in young but not adult mice after 3 days of THC treatment. Because our previous work illustrated age-dependent alterations to mRNA transcripts after chronic THC-treatment, we also performed quantitative real-time PCR to assess any age dependent differences of 3-day THC exposure on mRNA levels in the VTA. Quantitative PCR revealed no THC-induced changes for young or adult mice but did show several differences between young and adult control mice. This age-dependent impact of THC on synaptic activity could reveal a physiological mechanism underlying increased sensitivity of adolescents to THC-induced alterations to plasticity.
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