ReviewVirology journal2025
"Silent messengers of chaos: unveiling the dual threat of immune infiltrates in Japanese encephalitis virus neuroinflammatory storm".
Review in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- mRNA Vaccine Against Japanese Encephalitis Virus Genotype IV Protects Against Lethal Infection.Viruses · 2026Article
- Sequelae of viral CNS infections including outcomes, mechanisms, and knowledge gaps.Npj viruses · 2025Review
- Review of selected mosquito-borne diseases: arboviruses (dengue, chikungunya, Zika, West Nile, Japanese encephalitis, yellow fever) and parasitic diseases (malaria, lymphatic Filariasis).Frontiers in public health · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Japanese encephalitis virus (JEV), a neurotropic flavivirus, poses a formidable global health challenge due to its severe neurological sequelae and high lethality. Peripheral immune effectors, including monocytes, macrophages, dendritic cells, natural killer cells, and T lymphocytes, act as principal vectors of neuropathogenic exacerbation by translocating across a compromised blood-brain barrier (BBB). These cells perpetuate an inflammatory cascade within the central nervous system (CNS), characterized by unchecked cytokine dysregulation and collateral neuronal destruction. Exosomes, diminutive extracellular vesicles, emerge as cryptic propagators of JEV neuropathogenesis. Acting as molecular couriers, these vesicles disseminate viral RNA and proinflammatory mediators, thus orchestrating neuronal apoptosis and fostering a pernicious inflammatory microenvironment. Exosomal trafficking exacerbates BBB destabilization, potentiates immune cell ingress into the CNS, and establishes a deleterious feedback mechanism of neuroinflammation and cellular attrition. This review underscores the intricate crosstalk between peripheral immune infiltrates and exosomal vectors in JEV progression, advocating for advanced therapeutic paradigms aimed at intercepting exosomal biogenesis, attenuating immune hyperactivation, and preserving BBB integrity to mitigate CNS devastation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.