Evidence map›Paper›PMID 40450263›Full record

ArticleBMC pregnancy and childbirth2025

Study on characteristics of gut flora composition of pregnant women with preeclampsia.

Genxia Li, Huan Niu, Mingkun Xie, Manman Yang, Mengyu Li, Yujing Hao, Junya Zhang

Abstract read
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In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Genxia LiObstetrics Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. ligenxia@163.com.
Huan NiuObstetrics Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Mingkun XieObstetrics Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Manman YangObstetrics Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Mengyu LiObstetrics Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Yujing HaoObstetrics Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Junya ZhangObstetrics Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.

Funding

Medical Education Research Project of Henan Province Wjlx2016013Medical Science and Technology Project of Henan Province 2018020196Science and Technology Project of Henan Province 172102310399Suitable Technology Extension Project of Henan Province SYJS2022065
6 · The paper itself

Abstract

objectivesTo explore the relationship between preeclampsia and the changes of the intestinal microflora.

methodsIllumina HiSeq sequencing platform was used to sequencing the 16S rRNA of bacteria in stool samples from 54 pregnant women. The experimental group included 27 women with preeclampsia (PRE), consisting of 13 women with severe preeclampsia (SP) and 14 women with non-severe preeclampsia (P). The control group comprised 27 healthy pregnant women (NOR).

resultsThe bacterial Alpha diversity of the PRE group was higher than that of the normal group, but P>0.05. The dominant flora in the four groups were Bacteroidetes, Firmicutes, and Proteobacteria. The abundance of Synergistetes in the PRE group was significantly lower than that in normal group and Bacteroidetes in the P group was significantly higher than that in SP group, and Firmicutes in the P group was significantly lower than that in the SP group(P < 0.05). LEfSe analyses showed, there were 9 flora differences between PRE group and NOR group, between P and SP groups that only Ruminococcaceae showed a difference. Differential species screening showed, there are 3 flora were significantly different between the PRE vs. NOR groups (P < 0.05). There are 4 flora were significantly different between the P vs. SP groups (P < 0.05). Functional difference analysis showed significant differences in 8 signaling pathways between the NOR group and the PRE group and 11 signaling pathways between P group and SP group.

conclusionThere are significant changes in intestinal flora between preeclampsia patients and healthy controls, which may be involved in the regulation of the occurrence and development of preeclampsia.

Indexed as

Gastrointestinal MicrobiomePre-EclampsiaAdultBacillotaBacteroidetesCase-Control StudiesFecesFemaleHumansPregnancyProteobacteriaRNA, Ribosomal, 16SRNA, Ribosomal, 16SBiomarkerIntestinal floraMetabolic diseasesPreeclampsiaPregnancy

Identifiers

PMID40450263
PMCPMC12125917

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.