Evidence map›Paper›PMID 40450242›Full record

Trial reportBMC anesthesiology2025

Stellate ganglion block for preserving arteriovenous fistula in hemodialysis patients undergoing major lower limb orthopedic surgeries: randomized control trial.

Ayman Mohamady Eldemrdash, Soudy S Hammad, Tarek S Hemaida, Taha Tairy Dardeer, Ahmed Adel Mohsen, Ahmed Khalaf Fathy, Gamal Hendawy Shams

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06300658 (Stellate Ganglion Block for Preserving Arteriovenous Fistula in Hemodialysis Patients Undergoing Major Lower Limb Orthopedic Surgery), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06300658 naunknown statusnot on this map

Stellate Ganglion Block for Preserving Arteriovenous Fistula in Hemodialysis Patients Undergoing Major Lower Limb Orthopedic Surgery: A Randomized Controlled Trial

TypeinterventionalSponsorAswan UniversityRan2024 to 2025Enrolled50ConditionsStellate Ganglion Block, Arteriovenous Fistula, Hemodialysis, Major Lower Limb Orthopedic SurgeryArmsStellate ganglion block
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ayman Mohamady EldemrdashAnesthesiology, Surgical Intensive Care and Pain Medicine Department, Faculty of Medicine, Aswan University, Aswan, Egypt. aymaneldemrdash@yahoo.com.
Soudy S HammadAnesthesiology, Surgical Intensive Care and Pain Medicine Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Tarek S HemaidaAnesthesiology, Surgical Intensive Care and Pain Medicine Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Taha Tairy DardeerAnesthesiology, Surgical Intensive Care and Pain Medicine Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Ahmed Adel MohsenDiagnostic and Interventional Radiology Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Ahmed Khalaf FathyVascular Surgery Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Gamal Hendawy ShamsAnesthesiology, Surgical Intensive Care and Pain Medicine Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMajor lower limb orthopedic surgeries can lead to hemodynamic alterations and increase the risk of arteriovenous (AV)fistula thrombosis. This study assessed the role of stellate ganglion block (SGB) in preserving the AV fistulas in hemodialysis (HD)patients undergoing major lower limb orthopedic surgeries.

methodsIn this randomized, controlled, double-blind trial, 50 chronic renal failure patients (ASA physical status III, aged 21-75 years) scheduled for major lower limb orthopedic surgeries were randomized into two groups: Group S received an ultrasound-guided SGB before spinal anesthesia, while Group C received a sham procedure. AVF function was assessed using Doppler ultrasonography on postoperative days 1 and 7. Primary outcome was AVF flow rate. Secondary outcomes included peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index (RI), thrombosis rate, and functional failure.

resultsGroup S demonstrated significantly higher AVF flow rates on both postoperative day 1 (276.96 ± 49.66 ml/min vs. 217.44 ± 46.73 ml/min) and day 7 (254.96 ± 49.38 ml/min vs. 204.56 ± 47.11 ml/min), with large effect sizes (Cohen's d = 1.23 and 1.04, respectively; p < 0.001). PSV and EDV were significantly improved, and RI was significantly lower in Group S. Thrombosis (8% vs. 36%) and failure rates (32% vs. 64%) were significantly reduced compared to the control group (p < 0.05).

conclusionsPre-emptive stellate ganglion block was associated with significantly improved AVF flow rate postoperatively and reduced thrombosis and functional failure, suggesting its clinical benefit in maintaining AVF patency during major surgeries in HD patients.

trial registrationThis study was approved by the Ethical Committee of Aswan University Hospitals, Egypt (Institutional Review Board (IRB 900/2/24)) and registered on clinicaltrials.gov (ID: NCT06300658). The registration time of this experiment is 3/09/2024. The study protocol was designed and implemented in accordance with the CONSORT guidelines. The study protocol was conducted in compliance with the relevant guidelines and standards.

Indexed as

Arteriovenous Shunt, SurgicalAutonomic Nerve BlockOrthopedic ProceduresRenal DialysisStellate GanglionAdultAgedDouble-Blind MethodFemaleHumansKidney Failure, ChronicLower ExtremityMaleMiddle AgedYoung AdultArteriovenous fistulaComplicationFailureHemodialysisOrthopedicStellate ganglion block

Identifiers

PMID40450242
PMCPMC12125875

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.