Evidence map›Paper›PMID 40450240›Full record

Trial reportBMC complementary medicine and therapies2025

Efficacy and safety of Lignosus rhinocerus (Cooke) Ryvarden TM02

Jie Yi Eng, Po Lin Ooi, Mariam Zafirah, Mahmoud Danaee, Marniza Saad, Muhammad Fazril Mohamad Razif, Nor Aishah Taib, Chee Loong Lam, Zamri Chik, Shin-Yee Fung

Abstract readRandomized Controlled TrialClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Methodology of analysis of cognitive impairment in longitudinal randomized clinical trials in oncology: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jie Yi EngDepartment of Clinical Oncology, Universiti Malaya Medical Centre, Lembah Pantai, Kuala Lumpur, 59100, Malaysia.ORCID https://orcid.org/0009-0005-5469-6220
Po Lin OoiDepartment of Clinical Oncology, Universiti Malaya Medical Centre, Lembah Pantai, Kuala Lumpur, 59100, Malaysia.ORCID https://orcid.org/0000-0003-2170-603X
Mariam ZafirahDepartment of Clinical Oncology, Universiti Malaya Medical Centre, Lembah Pantai, Kuala Lumpur, 59100, Malaysia.ORCID https://orcid.org/0000-0003-0736-0917
Mahmoud DanaeeDepartment of Social Preventive Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.ORCID https://orcid.org/0000-0002-5014-5684
Marniza SaadDepartment of Clinical Oncology, Universiti Malaya Medical Centre, Lembah Pantai, Kuala Lumpur, 59100, Malaysia. marniza@ummc.edu.my.ORCID https://orcid.org/0000-0003-1511-6690
Muhammad Fazril Mohamad RazifDepartment of Molecular Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.ORCID http://orcid.org/0000-0002-3951-8136
Nor Aishah TaibDepartment of Surgery, Universiti Malaya Medical Centre, Lembah Pantai, Kuala Lumpur, 59100, Malaysia.ORCID https://orcid.org/0000-0001-8419-0478
Chee Loong LamDepartment of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.ORCID http://orcid.org/0000-0001-7643-3230
Zamri ChikDepartment of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.ORCID http://orcid.org/0000-0003-1770-8382
Shin-Yee FungDepartment of Molecular Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia. syfung@um.edu.my.ORCID http://orcid.org/0000-0002-9288-7328

Funding

Bantuan Khas Penyelidikan (BKP Special) BKP007-2023-KPTabung Penyelidikan Mahmood Merican Research Grant 2019 PV014-2019
6 · The paper itself

Abstract

purpose of studyThis study aimed to evaluate the safety and effectiveness of TM02

methodsThis phase II randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of TM02

resultsThe Global Health Status (GHS) score showed a significant within-patient effect across five visits (p = 0.001; F = 0.276). A trend toward improved physical functioning and reduced fatigue was observed in the TM02

conclusionsOur study found that TM02

Indexed as

Biological ProductsBreast NeoplasmsDietary SupplementsFatiguePolyporaceaeAdultAgedDouble-Blind MethodFemaleHumansMiddle AgedQuality of LifeBiological ProductsBreast cancerChemotherapyChemotherapy-induced cognitive impairmentChemotherapy-induced fatigueQuality of lifeTM02®

Identifiers

PMID40450240
PMCPMC12125795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.