ArticleBMC neurology2025
Sleep disorders in patients with multiple sclerosis.
Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between depressive symptoms and sleep quality in patients with multiple sclerosis: a systematic review and meta-analysis.BMC neurology · 2026Pooled it
- Shedding Light on Interaction Between Neurological Symptoms and Psychiatric Episodes in Multiple Sclerosis: Novel Hypothesis and Therapeutic Avenues.Molecular neurobiology · 2026Review
- Nabiximols improves sleep architecture in multiple sclerosis: A prospective polysomnographic study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Prevalence and Associations of Poor Sleep in Patients with Relapsing-Remitting Multiple Sclerosis on Disease-Modifying Therapy.Journal of clinical medicine · 2025Article
- Longitudinal changes in sleep quality, and their predictors in patients with multiple sclerosis.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple sclerosis (MS), affected about 2.8 million people worldwide in 2020, is often associated with sleep disorders. These disturbances may arise from the disease itself-such as pain-or as side effects of symptomatic and immunological treatments.
methodsThe present study is cross-sectional- analytic study. The population studied consists of MS patients living in Kashan city. The sample size under investigation is comprised of 174 patients diagnosed with MS. The information was gathered through demographic information questionnaires, the hospital anxiety and depression scale(HADS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Insomnia Severity Index (ISI), and Multiple Sclerosis Impact Scale (MSIS). The data were analyzed through Chi-square tests and logistic regression using Stata version 14 software.
resultsOf 174 MS patients (81.76% female, mean age 34.16 ± 7.62), Mild insomnia affected 17.05%, and 68.18% experienced frequent night awakenings. Significant predictors of sleepiness included education level (OR: 18.20; p = 0.03), insomnia severity (OR: 5.24; p = 0.04), and morning dysfunction (OR: 6.49; p = 0.04), as well as MS medication. Most patients were not taking sleep medication (86.05%). Mild anxiety and baseline depressive symptoms were prevalent (69.32% and 80.68%, respectively), and 80.11% reported low quality of life.
conclusionsThe final model demonstrated an effective relationship between the Sleepiness and variables of education level, drugs used in MS, Insomnia Severity, and morning dysfunction in the presence of other variables.
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