Evidence map›Paper›PMID 40450194›Full record

ArticleJournal of gastrointestinal cancer2025

Long-Term Oncological Outcomes After Complete Mesocolic Excision Versus Standard Resection for Right-Sided Colon Cancer: A Propensity Score Matching Analysis.

Federica Del Coco, Pietro Achilli, Pietro Carnevali, Irene Giusti, Alessandro Giani, Camillo Leonardo Bertoglio, Carmelo Magistro, Matteo Origi, Michele Mazzola, Giovanni Ferrari

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Federica Del CocoOspedale "G. Fornaroli", ASST Ovest Milanese, U.O. Chirurgia Generale, Via Al Donatore Di Sangue, 50, Magenta, MI, Italy. federica.delcoco18@gmail.com.
Pietro AchilliGrande Ospedale Metropolitano Niguarda, U.O. Chirurgia Oncologica Mininvasiva, Milan, MI, Italy.
Pietro CarnevaliGrande Ospedale Metropolitano Niguarda, U.O. Chirurgia Oncologica Mininvasiva, Milan, MI, Italy.
Irene GiustiGrande Ospedale Metropolitano Niguarda, U.O. Chirurgia Oncologica Mininvasiva, Milan, MI, Italy.
Alessandro GianiGrande Ospedale Metropolitano Niguarda, U.O. Chirurgia Oncologica Mininvasiva, Milan, MI, Italy.
Camillo Leonardo BertoglioOspedale "G. Fornaroli", ASST Ovest Milanese, U.O. Chirurgia Generale, Via Al Donatore Di Sangue, 50, Magenta, MI, Italy.
Carmelo MagistroOspedale Di Vizzolo Predabissi, ASST Melegnano Martesana, U.O. Chirurgia Generale, Melegnano, MI, Italy.
Matteo OrigiGrande Ospedale Metropolitano Niguarda, U.O. Chirurgia Oncologica Mininvasiva, Milan, MI, Italy.
Michele MazzolaGrande Ospedale Metropolitano Niguarda, U.O. Chirurgia Oncologica Mininvasiva, Milan, MI, Italy.
Giovanni FerrariGrande Ospedale Metropolitano Niguarda, U.O. Chirurgia Oncologica Mininvasiva, Milan, MI, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplete mesocolic excision (CME) has not gained wide diffusion, mainly due to its technical complexity and unclear oncological benefits. We investigated the long-term outcomes of patients with right-sided colon cancer who underwent CME surgery compared to those treated with conventional surgery (NCME).

methodsProspectively collected data of patients who underwent surgery between 2010 and 2018 were retrospectively analysed. Propensity score matching (PSM) was used to balance baseline characteristics of CME and NCME patients. The primary endpoints of the study were overall and disease-free survival (OS and DFS), distant and local recurrence-free survival (DRFS and LRFS).

resultsOut of the 444 patients included in the study, 254 were correctly matched after PSM, 127 in each group. The median follow-up was 70 months (IQR 54-81). Conversion rate, complications, and 90-day mortality were comparable in both groups. Five-year LRFS rates for CME patients was 100% and 95% for NCME (log-rank p = 0.044). At 5 years, there were no differences between the two groups in terms of overall survival and disease-free survival.

conclusionsLaparoscopic CME for RCC is associated with a significant decrease in terms of LRFS. No benefit on long-term disease-free survival and overall survival was obtained.

Indexed as

ColectomyColonic NeoplasmsLaparoscopyMesocolonAgedDisease-Free SurvivalFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm Recurrence, LocalPropensity ScoreRetrospective StudiesTreatment OutcomeComplete mesocolic excisionLocal recurrencePropensity score matchingRight colon cancer

Identifiers

PMID40450194

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.