ArticleJournal of gastrointestinal cancer2025
Impact of Environmental Quality on Pancreatic Cancer Outcomes Post Pancreatoduodenectomy: A Retrospective Cohort Study.
Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Contextual nonmedical health factors and critical care-related outcomes: a systematic review.Critical care (London, England) · 2025Pooled it
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe Environmental Quality Index (EQI), a composite measure of county-level environmental burden, has been linked to cancer incidence and disease progression. We evaluated the association between EQI and clinical characteristics and outcomes among patients undergoing pancreatoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC).
methodsWe conducted a retrospective cohort study of PDAC patients who underwent PD between 2014 and 2023. Patients were stratified into low, moderate, or high EQI groups. Multinomial regression models were used to assess associations between EQI levels and clinical variables, using the low EQI group as the reference.
resultsAmong the 137 patients with PDAC who underwent PD, 37 (27.1%) were in the low, 42 (30.6%) in the moderate, and 58 (42.3%) in the high EQI groups. The study identified significant associations in high EQI groups: race (minority vs. white patients: RR 2.44, p = 0.044); diabetes mellitus prevalence (RR 3.12, 95% CI 1.30-7.49, p = 0.011), tumor size > 5 cm (RR 1.53, p = 0.048), history of other types of cancer (RR 1.64, p = 0.038), longer time-to-treatment (RR 1.96, p = 0.041), and ICU stay > 3 days (RR 1.95, p = 0.013), compared to the low EQI group. No significant differences were observed in severe post-operative complications, mortality rates, or median overall survival across groups (mOS: 20.2 months for low, 15.2 months for moderate, and 14.2 months for high EQI, respectively, p = 0.210).
conclusionPatients residing in areas with poor environmental quality had higher comorbidity burden and delays in treatment, though EQI was not significantly associated with surgical or survival outcomes.
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