Evidence map›Paper›PMID 40450148›Full record

ArticleScientific reports2025

A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization.

Yusuke Sudo, Rio Kamashita, Tsunehiko Takamura, Sayo Hamatani, Noriko Numata, Koji Matsumoto, Yasuhiro Sato, Yumi Hamamoto, Tomotaka Shoji, Tomohiko Muratsubaki and 18 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

28 authors.

Yusuke SudoResearch Center for Child Mental Development Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Rio KamashitaResearch Center for Child Mental Development Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Tsunehiko TakamuraDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
Sayo HamataniResearch Center for Child Mental Development Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Noriko NumataResearch Center for Child Mental Development Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Koji MatsumotoDepartment of Radiology, Chiba University Hospital, Chiba, Japan.
Yasuhiro SatoDepartment of Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan.
Yumi HamamotoResearch Institute of Electrical Communication, Tohoku University, Sendai, Japan.
Tomotaka ShojiDepartment of Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan.
Tomohiko MuratsubakiDepartment of Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan.
Motoaki SugiuraDepartment of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Shin FukudoDepartment of Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan.
Michiko KawabataDepartment of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Momo SunadaDepartment of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Tomomi NodaDepartment of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Keima ToseDepartment of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Masanori IsobeDepartment of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Naoki KodamaDivision of Psychosomatic Medicine, Department of Neurology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Shingo KakedaDepartment of Radiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Masatoshi TakahashiDivision of Psychosomatic Medicine, Department of Neurology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Hiroaki AdachiDepartment of Neurology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, Japan.
Shu TakakuraDepartment of Psychosomatic Medicine, Kyushu University Hospital, Fukuoka, Japan.
Motoharu GondoDepartment of Psychosomatic Medicine, Kyushu University Hospital, Fukuoka, Japan.
Kazufumi YoshiharaDepartment of Psychosomatic Medicine, Kyushu University Hospital, Fukuoka, Japan.
Yoshiya MoriguchiDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
Eiji ShimizuResearch Center for Child Mental Development Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Atsushi SekiguchiDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
Yoshiyuki HiranoResearch Center for Child Mental Development Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan. hirano@chiba-u.jp.

Funding

Japan Agency for Medical Research and Development JP19dm0307104Japan Society for the Promotion of Science JP17K09286Japan Society for the Promotion of Science JP25460884Ministry of Health, Labour and Welfare H29-nanbyo-ippan
6 · The paper itself

Abstract

Although changes in insular function have been thought to play a central role in the pathophysiology of anorexia nervosa (AN), due to factors such as insufficient sample size, there have been no studies examining changes in resting-state functional connectivity (rsFC) between insula and whole brain in AN, based on functional localization of insula. Here, we subdivided insula into 6 regions per side based on functional localization and reanalyzed previously published functional magnetic resonance imaging data from 114 female patients with AN and 135 female healthy controls (HC). We calculated the rsFCs between ROIs and compared the results between groups, with the 12 insular regions serving as seed ROIs and 142 regions of the whole brain as target ROIs. Compared to HC, AN patients had a increased rsFC between dorsal anterior insula (daIC) and amygdala, and a decreased rsFC between posterior division of dorsal middle insula (pdmIC) and opercular cortex (false discovery rate [FDR] corrected p-value < 0.05 with analysis-level correction, which means that FDR correction was applied to all seed ROIs and all target ROI combinations). These rsFC changes may be the neurological basis for AN symptoms, such as hypersensitivity to negative stimuli, taste disorder, and enhanced taste aversion learning.

Indexed as

Anorexia NervosaCerebral CortexInsular CortexAdolescentAdultBrain MappingCase-Control StudiesConnectomeCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingRestYoung AdultAnorexia nervosaEating disorderInsulaResting-state functional connectivityTaste

Identifiers

PMID40450148
PMCPMC12126531

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