Evidence map›Paper›PMID 40450143›Full record

Observational studyScientific reports2025

The impact of elective spine surgery in Canada for degenerative conditions on patient reported health-related quality of life outcomes.

Ragavan Manoharan, Nisaharan Srikandarajah, Jean-Christophe Murray, Christopher Nielsen, Supriya Singh, Sean Christie, Michael M H Yang, Michael Weber, Bernard Larue, Adrienne Kelly and 14 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Ragavan Manoharan *University of Toronto Spine Program, Toronto Western Hospital, Toronto, ON, Canada.
Nisaharan Srikandarajah *University of Toronto Spine Program, Toronto Western Hospital, Toronto, ON, Canada.
Jean-Christophe MurrayDivision of Orthopaedic Surgery, Department of Surgery, CHU de Québec - Université Laval Quebec City, Quebec, QC, Canada.
Christopher NielsenSchroeder Arthritis Institute, Krembil Research Institute, Department of Surgery, Division of Orthopaedic Surgery, University Health Network, University of Toronto, Orthopaedics, Toronto, ON, Canada.
Supriya SinghLondon Health Science Centre Combined Orthopaedic and Neurosurgery Spine Program, Schulich School of Medicine, Western University, London, ON, Canada.
Sean ChristieDepartment of Surgery, Division of Neurosurgery, Dalhousie University, Halifax, NS, Canada.
Michael M H YangUniversity of Calgary Spine Program, University of Calgary, Calgary, AB, Canada.
Michael WeberDepartment of Surgery, Division of Orthopaedics, Montreal General Hospital, McGill University, Montreal, QC, Canada.
Bernard LarueDépartement de Chirurgie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Adrienne KellySault Area Hospital, Northern Ontario School of Medicine, Sault Ste Marie, Sault Ste. Marie, ON, Canada.
Jerome PaquetCentre de Recherche CHU de Quebec, CHU de Quebec-Universite Laval, Quebec City, QC, Canada.
Raphaele Charest-MorinCombined Neurosurgical and Orthopedic Spine Program, Department of Orthopedics Surgery, University of British Columbia, Vancouver, BC, Canada.
Guy HoganDepartment of Orthopaedic Surgery, Health Sciences Centre, Newfoundland and Labrador, St. John's, Canada.
Andrew GlennieDepartment of Surgery, Division of Orthopedics, Dalhousie University, Halifax, NS, Canada.
Henry AnhDivision of Orthopaedic Surgery, St. Michael's Hospital, Toronto, ON, Canada.
Eugene WaiDivision of Orthopaedic Surgery, University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada.
Nicolas DeaCombined Neurosurgical and Orthopedic Spine Program, Department of Orthopedics Surgery, University of British Columbia, Vancouver, BC, Canada.
Neil MasonCanada East Spine Centre, Division of Orthopaedic Surgery, Horizon Health Network, Zone 2, Saint John, New Brunswick, Canada.
Kenneth ThomasUniversity of Calgary Spine Program, University of Calgary, Calgary, AB, Canada.
Charles FisherCombined Neurosurgical and Orthopedic Spine Program, Department of Orthopedics Surgery, University of British Columbia, Vancouver, BC, Canada.
Hamilton HallDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
Christopher BaileyLondon Health Science Centre Combined Orthopaedic and Neurosurgery Spine Program, Schulich School of Medicine, Western University, London, ON, Canada.
Mayilee CanizaresSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Yoga Raja RampersaudSchroeder Arthritis Institute, Krembil Research Institute, Department of Surgery, Division of Orthopaedic Surgery, University Health Network, University of Toronto, Orthopaedics, Toronto, ON, Canada. raja.rampersaud@uhn.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of spine surgery on Health-Related Quality-of-Life (HRQoL) outcomes across common spinal degenerative diagnoses is not well characterised. A prospective observational study of patients enrolled in the Canadian Spine Outcomes and Research Network (CSORN) registry was performed. Baseline and 1-year post-operative Short Form-12 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores were collated and compared to normative values from the Canadian General Population (CGP). The percentage of patients achieving the PCS Minimum Clinically Important Difference (MCID) was quantified. 5049 patients were included in the analysis. The mean pre-operative SF-12 PCS was 29.5 and MCS was 44.1. This improved to a mean PCS of 40.5 (p < 0.001) and MCS of 49.3 (p < 0.0001) at 1-year post-operatively. The mean pre-operative PCS was over 2 standard deviations (SD) lower than the normative mean of the CGP; this improved to being close to 1-SD from the normative CGP mean at 1-year post-operatively. Findings were similar across age- and sex-stratified subgroups. Across all conditions, 70-75% of patients achieved the PCS MCID. Fewer patients with cervical myelopathy achieved the PCS MCID (59%). In a surgical cohort, patients with degenerative spinal conditions demonstrate a profound reduction in PCS compared to their peers in the CGP. Spinal surgery was impactful in improving physical function HRQoL outcomes in the majority, but not typically to average population norms.

Indexed as

Elective Surgical ProceduresPatient Reported Outcome MeasuresQuality of LifeSpinal DiseasesSpineAdultAgedCanadaFemaleHumansMaleMiddle AgedProspective StudiesRegistriesTreatment OutcomeDegenerative spinal conditionsSpinal health-related quality of life outcomesSpine surgery

Identifiers

PMID40450143
PMCPMC12126512

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.