Evidence map›Paper›PMID 40450135›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025

Painful symptoms and spine-specific activity limitations associated with dural ectasia in individuals with Marfan syndrome: a cross-sectional comparative study (MARFANLOMB).

Sébastien Troussier, Olivier Milleron, François Rannou, Ludivine Eliahou, Guillaume Jondeau, Christelle Nguyen

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05123339 (Clinical Signs and Activity Limitations Associated With Dural Ectasia in Patients With Marfan Disease), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05123339 completednot on this map

Clinical Signs and Activity Limitations Associated With Dural Ectasia in Patients With Marfan Disease: Cross-sectional Case-control Study.

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2022 to 2022Enrolled90ConditionsMarfan SyndromeArmsQuestionnaire
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sébastien TroussierAP-HP.Centre-Université Paris Cité, Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Hôpital Cochin, Paris, 75014, France.
Olivier MilleronAP-HP.Nord-Université Paris Cité, Service de Cardiologie, Hôpital Bichat, Paris, 75018, France.
François RannouAP-HP.Centre-Université Paris Cité, Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Hôpital Cochin, Paris, 75014, France.
Ludivine EliahouAP-HP.Nord-Université Paris Cité, Service de Cardiologie, Hôpital Bichat, Paris, 75018, France.
Guillaume JondeauAP-HP.Nord-Université Paris Cité, Service de Cardiologie, Hôpital Bichat, Paris, 75018, France.
Christelle NguyenAP-HP.Centre-Université Paris Cité, Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Hôpital Cochin, Paris, 75014, France. christelle.nguyen2@aphp.fr.ORCID 0000-0001-7141-3230

Funding

ADERPOS, Association pour le Développement de l'Enseignement et de la Recherche dans la Pathologie Ostéoarticulaire et Sportive NA
6 · The paper itself

Abstract

purposeTo compare frequencies and characteristics of painful symptoms, spine-specific activity limitations and health-related quality of life, between individuals with Marfan syndrome with dural ectasia, and those without.

methodsWe conducted a cross-sectional comparative study. All individuals with Marfan syndrome followed in a single center were screened. The presence of dural ectasia was assessed using CT-scan or magnetic resonance imaging. Endpoints were the frequencies and characteristics of painful symptoms, spine-specific activity limitations and health-related quality of life.

resultsOverall, 90 individuals were included: 86 (96%) had FBN1 mutations, 55 (61%) had dural ectasia and 35 (39%) had not. Mean age was 39.3 (9.4) years, 45 (50%) were women and 80 (89%) had back pain. The frequencies of headache with upright posture and of pain in the lower back when coughing, laughing and/or sneezing were numerically higher in participants with dural ectasia (49% vs. 26% and 13% vs. 0%, respectively). We found no difference between the 2 groups for health-related quality of life.

conclusionIndividuals with Marfan syndrome and dural ectasia, as compared to individuals with Marfan syndrome without dural ectasia, could display a specific pattern of painful symptoms, including lower back pain and headache with upright posture. However, none of the comparisons performed reached statistically significant difference.

Indexed as

Back PainDura MaterMarfan SyndromeAdultCross-Sectional StudiesDilatation, PathologicFemaleHumansMaleMiddle AgedQuality of LifeDisabilityDural ectasiaHealth-related quality of lifeLower back painMarfan syndrome

Identifiers

PMID40450135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.