Evidence map›Paper›PMID 40450132›Full record

ArticleCommunications biology2025

Sustained strain applied at high rates drives dynamic tensioning in epithelial cells.

Bahareh Tajvidi Safa, Jordan Rosenbohm, Amir Monemian Esfahani, Grayson Minnick, Amir Ostadi Moghaddam, Nickolay V Lavrik, Changjin Huang, Guillaume Charras, Alexandre Kabla, Ruiguo Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Bahareh Tajvidi SafaDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.
Jordan RosenbohmDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID http://orcid.org/0009-0008-1916-0879
Amir Monemian EsfahaniDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID http://orcid.org/0000-0003-4800-0467
Grayson MinnickDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE, USA.
Amir Ostadi MoghaddamDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.
Nickolay V LavrikCenter for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, USA.ORCID http://orcid.org/0000-0002-9543-5634
Changjin HuangSchool of Mechanical & Aerospace Engineering, Nanyang Technological University, Singapore, Republic of Singapore.ORCID http://orcid.org/0000-0002-1941-1200
Guillaume CharrasLondon Centre for Nanotechnology, University College London, London, UK.ORCID http://orcid.org/0000-0002-7902-0279
Alexandre KablaDepartment of Engineering, University of Cambridge, Cambridge, UK. ajk61@cam.ac.uk.ORCID http://orcid.org/0000-0002-0280-3531
Ruiguo YangDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, USA. yangruig@msu.edu.ORCID http://orcid.org/0000-0002-1361-4277

Funding

Direct and Quantitative Probing of Desmosome MechanotransductionR35GM150623 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Ruiguo Yang · 2023 to 2026
$1.5M
National Science Foundation (NSF) 1826135National Science Foundation (NSF) 2143997NIGMS NIH HHS R35 GM150623
6 · The paper itself

Abstract

Epithelial cells experience long lasting loads of different magnitudes and rates. How they adapt to these loads strongly impacts tissue health. Yet, much remains unknown about the evolution of cellular stress in response to sustained strain. Here, by subjecting cell pairs to sustained strain, we report a bimodal stress response, where in addition to the typically observed stress relaxation, a subset of cells exhibits a dynamic tensioning process with significant elevation in stress within 100 s, resembling active pulling-back in muscle fibers. Strikingly, the fraction of cells exhibiting tensioning increases with increasing strain rate. The tensioning response is accompanied by actin remodeling, and perturbation to actin abrogates it, supporting cell contractility's role in the response. Collectively, our data show that epithelial cells adjust their tensional states over short timescales in a strain-rate dependent manner to adapt to sustained strains, demonstrating that the active pulling-back behavior could be a common protective mechanism against environmental stress.

Indexed as

Epithelial CellsStress, MechanicalActinsAnimalsBiomechanical PhenomenaHumansActins

Identifiers

PMID40450132
PMCPMC12126506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.