Evidence map›Paper›PMID 40450126›Full record

ArticleDrug delivery and translational research2026

Assessment of leachables and extractables in "super-swelling" hydrogel-forming microarray patches.

Qonita Kurnia Anjani, Peter E McKenna, Eneko Larrañeta, Panagiotis Manesiotis, Yidan Luo, Masoud Adhami, Fabiana Volpe-Zanutto, Gareth Orr, Sabrina Roussel, Ryan F Donnelly

Abstract read
In one paragraph

Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qonita Kurnia AnjaniSchool of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Peter E McKennaSchool of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Eneko LarrañetaSchool of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Panagiotis ManesiotisSchool of Chemistry and Chemical Engineering, David Keir Building, 39-123 Stranmillis Road, Belfast, BT9 5 AG, UK.
Yidan LuoSchool of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Masoud AdhamiSchool of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Fabiana Volpe-ZanuttoSchool of Biomedical Sciences, Mass Spectrometry Centre, Ulster University, Cromore Road, Coleraine, BT52 1SA, UK.
Gareth OrrSchool of Biomedical Sciences, Mass Spectrometry Centre, Ulster University, Cromore Road, Coleraine, BT52 1SA, UK.
Sabrina RousselSchool of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Ryan F DonnellySchool of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. r.donnelly@qub.ac.uk.ORCID https://orcid.org/0000-0002-0766-4147

Funding

Engineering and Physical Sciences Research Council EP/V047221/1
6 · The paper itself

Abstract

Hydrogel-forming microarray patches (MAPs) offer a minimally invasive platform for transdermal drug delivery, enabling systemic absorption of active pharmaceutical ingredients. Unlike dissolving MAPs, which deposit their entire polymer matrix into the skin, hydrogel-forming MAPs remain intact upon removal, reducing polymer exposure while delivering higher drug doses than dissolving or coated MAPs. Moreover, they have demonstrated excellent biocompatibility and do not cause skin or systemic issues, even with repeated application in humans. This study assessed the leachable and extractable compounds from hydrogel-forming MAPs composed of Gantrez

Indexed as

Drug Delivery SystemsHydrogelsPolyethylene GlycolsTransdermal PatchAdministration, CutaneousCarbonatesHumansCarbonatesHydrogelsPolyethylene Glycolssodium carbonateExtractablesHydrogel-forming microarray patchesLeachablesMicroneedlesTransdermal

Identifiers

PMID40450126
PMCPMC12682715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.