Evidence map›Paper›PMID 40450089›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

PXA-like tumors: prognostic implications.

Supriya Bhardwaj, Hemlata Jangir, Swati Singh, Jyotsna Singh, Mehar Chand Sharma, Ashish Suri, Shweta Kedia, Ajay Garg, Chitra Sarkar, Vaishali Suri

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Supriya BhardwajNeuropathology Laboratory, All India Institute of Medical Sciences, New Delhi, India.
Hemlata JangirNeuropathology Laboratory, All India Institute of Medical Sciences, New Delhi, India.
Swati SinghNeuropathology Laboratory, All India Institute of Medical Sciences, New Delhi, India.
Jyotsna SinghNeuropathology Laboratory, All India Institute of Medical Sciences, New Delhi, India.
Mehar Chand SharmaNeuropathology Laboratory, All India Institute of Medical Sciences, New Delhi, India.
Ashish SuriDepartment of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
Shweta KediaDepartment of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
Ajay GargDepartment of Neuroradiology, Institute of Medical Science, All India, New Delhi, India.
Chitra SarkarDepartment of Pathology, All India Institute of Medical Science, New Delhi, India.
Vaishali SuriNeuropathology Laboratory, All India Institute of Medical Sciences, New Delhi, India. surivaishali@yahoo.co.in.ORCID http://orcid.org/0000-0001-6485-8194

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe classification of central nervous system (CNS) tumors has evolved significantly with the integration of molecular markers, particularly through DNA methylation profiling. We aimed to explore the disparity between epigenetic profiling, histomorphology, and CNS WHO grade by analyzing the therapeutic and survival duration of the patients.

methodThis retrospective study evaluated three ambiguous pediatric cases, aged 9 to 15 years, with a radiological diagnosis of high-grade glioma. A multidisciplinary approach assessed the discordance between histomorphology, epigenetic profiling, CNS WHO grade, and overall survival.

resultsBased on the 5th edition CNS WHO classification, two cases were diagnosed as diffuse pediatric-type high-grade gliomas (PHGG), H3 wild type, IDH wild type, NOS. One of the cases exhibited a BRAF V600E mutation and was classified as glioblastoma with BRAF V600E mutation. DNA methylation profiling using the Heidelberg/DKFZ Classifier classified all three cases as pleomorphic xanthoastrocytoma (PXA), despite a mean survival of only 13.7 months.

conclusionThe study highlights that the methylation class PXA comprises tumors which can exhibit high-grade features and a poor prognosis.

Indexed as

AstrocytomaBrain NeoplasmsAdolescentChildDNA MethylationHumansMutationPrognosisProto-Oncogene Proteins B-rafRetrospective StudiesProto-Oncogene Proteins B-rafBRAF V600E mutationDKFZ methylation classifierDNA methylationPediatric high-grade gliomasPleomorphic xanthoastrocytomaPTERT

Identifiers

PMID40450089

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