Evidence map›Paper›PMID 40450079›Full record

ArticleScientific data2025

MSLesSeg: baseline and benchmarking of a new Multiple Sclerosis Lesion Segmentation dataset.

Francesco Guarnera, Alessia Rondinella, Elena Crispino, Giulia Russo, Clara Di Lorenzo, Davide Maimone, Francesco Pappalardo, Sebastiano Battiato

Abstract readDataset
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Rethinking MS Therapeutics: From Disease Pathogenesis Mechanisms to AI-Driven Drug Discovery.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Review
  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesco GuarneraDepartment of Mathematics and Computer Science, University of Catania, Catania, Italy. francesco.guarnera@unict.it.
Alessia RondinellaDepartment of Mathematics and Computer Science, University of Catania, Catania, Italy. alessia.rondinella@unict.it.ORCID http://orcid.org/0000-0002-6825-8708
Elena CrispinoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Giulia RussoDepartment of Drug and Health Sciences, University of Catania, Catania, Italy.
Clara Di LorenzoUOC Radiologia, ARNAS Garibaldi, Catania, Italy.
Davide MaimoneCentro Sclerosi Multipla, UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy.
Francesco PappalardoDepartment of Drug and Health Sciences, University of Catania, Catania, Italy.
Sebastiano BattiatoDepartment of Mathematics and Computer Science, University of Catania, Catania, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper presents MSLesSeg, a new, publicly accessible MRI dataset designed to advance research in Multiple Sclerosis (MS) lesion segmentation. The dataset comprises 115 scans of 75 patients including T1, T2 and FLAIR sequences, along with supplementary clinical data collected across different sources. Expert-validated annotations provide high-quality lesion segmentation labels, establishing a reliable human-labeled dataset for benchmarking. Part of the dataset was shared with expert scientists with the aim to compare the last automatic AI-based image segmentation solutions with an expert-biased handmade segmentation. In addition, an AI-based lesion segmentation of MSLesSeg was developed and technically validated against the last state-of-the-art methods. The dataset, the detailed analysis of researcher contributions, and the baseline results presented here mark a significant milestone for advancing automated MS lesion segmentation research.

Indexed as

Magnetic Resonance ImagingMultiple SclerosisBenchmarkingHumansImage Processing, Computer-Assisted

Identifiers

PMID40450079
PMCPMC12126551

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.