ArticleBrain structure & function2025
Animal models are useful in studying human neuroanatomy with tractography.
Article in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Longitudinal tractography of the mouse corpus callosum reveals topographical order and differences due to sex and aging.Brain structure & function · 2025Article
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8 authors.
Funding
Abstract
Despite the impact of tractography on human brain mapping, direct validation and biological interpretation remain challenging. This short communication summarizes the key points of a debate held at the 2024 Tract-Anat Retreat on whether animal models are useful for studying human neuroanatomy with diffusion MRI tractography. While recognizing limitations, such as anatomical and biological differences between species, hardware and acquisition considerations and direct translation and interpretation, we identified immense value and utility of animal models for tractography including validation with histology, acquiring high-resolution datasets, exploring disease mechanisms, and advancing comparative neuroanatomy. These perspectives highlight the translational potential of preclinical models to inform tractography methodologies and underscore the need for careful species selection, methodological rigor, and ethical oversight in cross-species neuroimaging research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.