Evidence map›Paper›PMID 40450023›Full record

ArticleNPJ Regenerative medicine2025

Genetic compensation response contributes to Pleurodeles waltl limb regeneration.

Binxu Yin, Changhao Yu, Yang Liu, Hao Cai, Wencheng Wu, Tingting Ye, Lei Wang, Lujia Xiao, Yi Zhu, Huaijuan Guo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Binxu Yin *Central Laboratory and Orthopedic Department, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. yin_binxu@uestc.edu.cn.
Changhao Yu *College of Animal Science, Shandong Provincial Key Laboratory for Animal Germplasm Innovation & Utilization, Shandong Agricultural University, Taian, China.
Yang Liu *Central Laboratory and Orthopedic Department, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Hao Cai *College of Animal Science, Shandong Provincial Key Laboratory for Animal Germplasm Innovation & Utilization, Shandong Agricultural University, Taian, China.
Wencheng WuCentral Laboratory and Orthopedic Department, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Tingting YeCollege of Animal Science, Shandong Provincial Key Laboratory for Animal Germplasm Innovation & Utilization, Shandong Agricultural University, Taian, China.
Lei WangCentral Laboratory and Orthopedic Department, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Lujia XiaoCentral Laboratory and Orthopedic Department, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Yi ZhuCentral Laboratory and Orthopedic Department, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Huaijuan GuoCentral Laboratory and Orthopedic Department, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Kun ZhangCentral Laboratory and Orthopedic Department, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. zhangkun2023@uestc.edu.cn.
Heng WangCollege of Animal Science, Shandong Provincial Key Laboratory for Animal Germplasm Innovation & Utilization, Shandong Agricultural University, Taian, China. wangheng@sdau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hippo-Yap/Taz pathway is essential for tissue regeneration in multiple species. However, we found that in the highly regenerative salamanders, Yap knockout does not compromise the limb regeneration due to genetic compensation response (GCR). Specifically, the mutated Yap locus derived non-sense mRNA, which was recognized by UPF3A to instruct compensatory Taz induction. Blocking Yap mRNA or protein indeed inhibits regeneration. GCR could be utilized to maintain the robustness of limb regeneration.

Identifiers

PMID40450023
PMCPMC12126524

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.