ArticleNature communications2025
Photochemical C3-amination of pyridines via Zincke imine intermediates.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- Article
- Radical enantioconvergent meta-C─H alkylation of pyridines.Science advances · 2026Article
- Emerging Strategies forJACS Au · 2026Review
- Trifluoromethylation of pyridines through skeletal rearrangement.Chemical science · 2026Article
- C3-H methylenephosphonylation of azaarenes enabled by catalyst-controlled regioselective cyclizative rearrangement.Chemical science · 2026Article
- Article
- Photochemical C4-Selective C-H Amination of Quinolines viaOrganic letters · 2026Article
- Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways.Angewandte Chemie (International ed. in English) · 2026Article
- Synthesis andOrganic letters · 2025Article
- Formal pyridine meta-azidation and its application for the synthesis of diazepines, ring-fused δ-carbolines and 1,2,3-triazolylpyridines.Nature communications · 2025Article
- Synthesis of Thiophenes from Pyridines Using Elemental Sulfur.Angewandte Chemie (International ed. in English) · 2025Article
- Photochemical C3-amination of pyridines via Zincke imine intermediates.Nature communications · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Selective skeletal and peripheral editing of the pyridine moiety has broadly expanded the chemical space. While C-H functionalization at C2 and C4 positions are enabled by the inherent reactivity of this heteroarene, selective derivatization at the C3 position has long posed a significant challenge. Recently, based on a dearomatization-rearomatization sequence, involving Zincke imine intermediates, selective halogenation (-Br, -Cl, and -I) and isotopic labelling were accomplished. Here, we report a mild and regioselective method for C3-amination that relies on the photochemical reaction of Zincke imine with an amidyl radical generated from N-aminopyridinium salts. Mechanistic and theoretical studies indicate that radical intermediates are involved and explain the C3 regioselectivity of the reaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.