ArticleNature communications2025
The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
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Who cites it
9 citing papers in PubMed.
- Distinct roles of the JADE and BRPF scaffolding subunits of the acetyltransferase HBO1 complex.Nature communications · 2026Article
- The role of electrostatic interactions in the phase separation of HP1α and its protein binding partners.bioRxiv : the preprint server for biology · 2026Article
- Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits.Cell biochemistry and function · 2026Review
- Sensing the storm: how inflammatory signalling drives reactivation of the human cytomegalovirus major immediate-early promoter.The Journal of general virology · 2026Review
- Roles of TIF1β in Leukemic Stem Cell Through SETDB1-Dependent and Independent Mechanisms.Cancer science · 2026Review
- Shugoshin 2A stabilizes heterochromatin complexes to suppress the 2-cell-like state in embryonic stem cells.Stem cell reports · 2026Article
- A tryptophan-phenylalanine binding motif for the histone methyltransferases MLL4 and MLL3.The Journal of biological chemistry · 2026Article
- SFPQ directs histone H3.3 deposition to R-loops in DNA repeats to protect genome stability.Nature communications · 2026Article
- HP1γ self-assembles and cooperates with KAP1 in repression of long noncoding RNA AI662270 in ESCs.Cell reports · 2026Article
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Authors and funding
24 authors.
Nitika Gaurav *Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-6567-758X
Ryan O'Hara *Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-0188-0316
Usman HyderDepartment of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-7655-1533
Weihua QinDepartment of Biology II, Ludwig-Maximilians-Universität München, München, Germany.
Cheenou HerDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Hector RomeroDepartment of Biology, Technical University of Darmstadt, Darmstadt, Germany.ORCID http://orcid.org/0000-0002-2521-0034
Amarjeet KumarInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan.ORCID http://orcid.org/0000-0001-7740-9881
Maria J MarcaidaInstitute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0663-5309
Rohit K SinghDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
Ruud HoviusInstitute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Karthik SelvamDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-6140-0129
Jiuyang LiuDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
Sara MartireCecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-1570-3476
Yuhang YaoCecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0009-0006-5950-3245
Ashwini ChallaDepartment of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Matteo Dal PeraroInstitute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-2973-3975
Beat FierzInstitute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-2991-3044
Hidetoshi KonoInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan.ORCID http://orcid.org/0000-0001-5729-8707
M Cristina CardosoDepartment of Biology, Technical University of Darmstadt, Darmstadt, Germany.ORCID http://orcid.org/0000-0001-8427-8859
Galia T DebelouchinaDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6775-9415
Heinrich LeonhardtDepartment of Biology II, Ludwig-Maximilians-Universität München, München, Germany.ORCID http://orcid.org/0000-0002-5086-6449
Iván D'OrsoDepartment of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Ivan.Dorso@UTSouthwestern.edu.ORCID http://orcid.org/0000-0002-1409-2351
Laura A BanaszynskiCecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX, USA. laura.banaszynski@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-5189-8848
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. tatiana.kutateladze@cuanschutz.edu.ORCID http://orcid.org/0000-0001-7375-6990
Funding
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JONATHAN Charles COHEN · 2022 to 2026
$7.4MTranscriptional regulatory mechanisms shaping HIV proviral fateR01AI114362 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI D'ORSO, IVAN · 2015 to 2024
$4.6MChromatin Dynamics and Genome RegulationR35GM124958 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Laura Banaszynski · 2017 to 2026
$4.4MStructural biology of chromatin in vitro and in cellsR35GM138382 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Galia Debelouchina · 2020 to 2026
$2.8MMechanisms of p300 Activation During Pluripotency and Differentiation.R01HD109239 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI Laura Banaszynski · 2022 to 2026
$2.1MTargeting acetylated histone H4 by MLL4R01AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2021 to 2025
$2.1MMolecular analysis of ASH1LR01CA252707 · NCI · UNIVERSITY OF COLORADO DENVER · PI TATIANA G KUTATELADZE · 2020 to 2026
$1.9MThe role of JADE in HBO complexesR01HL151334 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.8MTargeting acetylated histone H4 by MLL4R56AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2020
$512kExploiting Oncogenic Chromatin Regulators in Cancer Initiation and ProgressionK00CA264296 · NCI · UNIVERSITY OF COLORADO DENVER · PI Usman Hyder · 2024 to 2026
$295kExploiting Oncogenic Chromatin Regulators in Cancer Initiation and ProgressionF99CA264296 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HYDER, USMAN · 2021 to 2022
$72kNCI NIH HHS F99 CA264296NCI NIH HHS K00 CA264296NCI NIH HHS R01 CA252707NHLBI NIH HHS R01 HL151334NIAID NIH HHS R01 AI114362NIA NIH HHS R01 AG067664NIA NIH HHS R56 AG067664NICHD NIH HHS R01 HD109239NIDDK NIH HHS P30 DK127984NIGMS NIH HHS R35 GM124958NIGMS NIH HHS R35 GM138382U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA252707U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL151334U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG067664
Abstract
Repression of endogenous retroviral elements (ERVs) is facilitated by KAP1 (KRAB-associated protein 1)-containing complexes, however the underlying mechanism remains unclear. Here, we show that binding of KAP1 to the major component of the heterochromatin spreading and maintenance network, HP1α, plays a critical role in silencing of repetitive elements. Structural, biochemical and mutagenesis studies demonstrate that the association of the HP1 box of KAP1 (KAP1
Indexed as
Chromosomal Proteins, Non-HistoneEmbryonic Stem CellsEndogenous RetrovirusesGene SilencingMouse Embryonic Stem CellsTripartite Motif-Containing Protein 28AnimalsChromatinChromobox Protein Homolog 5HeterochromatinHumansMiceMice, KnockoutProtein BindingChromatinChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneHeterochromatinTRIM28 protein, humanTrim28 protein, mouseTripartite Motif-Containing Protein 28
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