Evidence map›Paper›PMID 40449806›Full record

ArticleThe Journal of infection2025

Peripheral blood CD4

Lorena V N Oliveira, Jessica C Hargarten, Ruiying Wang, Diana Carlson, Yoon-Dong Park, Charles A Specht, Peter R Williamson, Stuart M Levitz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Study on the Enrichment Effect ofMicroorganisms · 2025
    Article
  5. Article
  6. Review
  7. CD8Immunology and cell biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lorena V N OliveiraDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jessica C HargartenLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Ruiying WangDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Diana CarlsonDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Yoon-Dong ParkLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Charles A SpechtDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Peter R WilliamsonLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Stuart M LevitzDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: stuart.levitz@umassmed.edu.

Funding

Preclinical studies of a Cryptococcus vaccine for AIDS patientsR01AI125045 · NIAID · WASHINGTON UNIVERSITY · PI LEVITZ, STUART MICHAEL, LODGE, JENNIFER K. · 2016 to 2025
$7.1M
Large Scale T Cell Epitope Discovery75N93019C00064 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAGE, KASIA · 2019 to 2024
$6.3M
A subunit Cryptococcus vaccineR01AI172154 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Stuart Michael Levitz · 2022 to 2026
$3.1M
NIAID NIH HHS 75N93019C00064NIAID NIH HHS R01 AI125045NIAID NIH HHS R01 AI172154
6 · The paper itself

Abstract

Immunological studies of persons with cryptococcal disease without known immunocompromise could inform vaccine development and identify novel requirements for antifungal immunity. We tested recall responses to heat-killed (HK) Cryptococcus and recombinant cryptococcal candidate vaccine antigens in peripheral blood T cells from subjects with a history of cryptococcosis and no recognized predisposing condition at the time of study enrollment, alongside healthy controls. In response to stimulation with HK Cryptococcus, CD4

Indexed as

Antigens, FungalCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCryptococcosisCryptococcusFungal VaccinesAdultAgedAnimalsDisease Models, AnimalFemaleHumansInterferon-gammaInterleukin-17MaleMiceAntigens, FungalFungal VaccinesInterferon-gammaInterleukin-17Antifungal immunityAntigen-specific T cell activationCD4(+) and CD8(+) T cellsCryptococcal meningitisFungal vaccinesHuman PBMCsMedical mycology

Identifiers

PMID40449806
PMCPMC12212068

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.