Evidence map›Paper›PMID 40449737›Full record

ArticleAntiviral research2025

Suppression of poxvirus replication by SC144.

Anil Pant, Djamal Brahim Belhaouari, Lara Dsouza, Lalita Priyamvada, Ziyue Wang, Santiago Navarro-Forero, Panayampalli S Satheshkumar, Zhengqiang Wang, Zhilong Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anil PantDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Djamal Brahim BelhaouariDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Lara DsouzaDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Lalita PriyamvadaPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Ziyue WangDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Santiago Navarro-ForeroDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Panayampalli S SatheshkumarPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Zhengqiang WangCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN, 55455, USA.
Zhilong YangDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA. Electronic address: zhilongyang@tamu.edu.

Funding

Development of novel antivirals against mpox (monkeypox) virusR01AI183580 · NIAID · UNIVERSITY OF MINNESOTA · PI Zhengqiang Wang, Zhilong Yang · 2024 to 2026
$2.3M
NIAID NIH HHS R01 AI183580
6 · The paper itself

Abstract

Poxviruses are a significant threat to the health of human and economically important animals. Although smallpox, one of the most devastating infectious diseases, is eradicated, the rapid rise of mpox and other poxviral diseases call for the development of antivirals. Here, we show that SC144, a reported small molecule inhibitor of cellular gp130 pathway, suppresses the replication of monkeypox, cowpox, and vaccinia viruses in cultured cells. Interestingly, SC144 likely suppresses vaccinia virus replication independent of gp130. We further show that this suppression of poxvirus replication is achieved by inhibiting viral DNA replication. With EC

Indexed as

Antiviral AgentsPoxviridaeVaccinia virusVirus ReplicationAnimalsCell LineCowpox virusDNA ReplicationHumansMonkeypox virusAntiviral AgentsAntiviralDNA replicationMonkeypox(mpox) virusPoxvirusesSC144Vaccinia virus

Identifiers

PMID40449737
PMCPMC12703941

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.