ArticleJournal of the National Cancer Institute2025
Sexual health outcomes after colorectal cancer diagnosis in females: a population-based cohort study.
Article in Journal of the National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundColorectal cancer (CRC) affects a growing number of females. Our objective was to evaluate the impact of CRC on sexual health outcomes among females, while controlling for age.
methodsWe conducted a cohort study using administrative health data from the province of British Columbia (BC) including linked health visits and cancer registry from 1985 to 2017. The cohort included females with CRC (n = 25 402; mean age [SD]: 69.0 [13.1]) and matched controls without CRC (n = 254 020; 69.0 [13.1]) in a 1:10 ratio by age, further stratified by age groups (≤39 years and ≥40 years). Multivariable Cox regression models assessed the associations between CRC and 5 sexual health outcomes (dyspareunia, pelvic inflammatory disease, endometriosis, abnormal bleeding, and premature ovarian failure), adjusting for covariates. Sensitivity analyses focused on females with CRC to explore associations between sociodemographic and cancer-related factors and sexual health outcomes. Tests were 2-sided (statistical significance P <.05).
resultsFemales with CRC had higher risks of dyspareunia (HR 1.67; 95% CI = 1.62 to 1.73), pelvic inflammatory disease (HR 3.42; 95% CI = 3.07 to 3.81), and endometriosis (HR 1.95; 95% CI = 1.69 to 2.25) compared to controls. In the ≥40-year group, these associations persisted, while in the ≤39-year group, endometriosis was not associated with CRC, but premature ovarian failure was (HR 1.75; 95% CI = 1.40 to 2.19). In sensitivity analyses, we also observed associations with cancer treatments (surgery, chemotherapy, radiation) and sexual health outcomes.
conclusionsThis population-based study identified associations between CRC and adverse sexual health outcomes among female patients, highlighting the need for targeted interventions and support.
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