Evidence map›Paper›PMID 40449488›Full record

ArticleCell host & microbe2025

Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway.

Eric M Brown, Emily R Temple, Sarah Jeanfavre, Julian Avila-Pacheco, Noel Taylor, Kai Liu, Phuong N U Nguyen, Ahmed M T Mohamed, Panhasith Ung, Rebecca A Walker and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Infection and immunity · 2026
    Article
  8. Review
  9. A Microbial Lipid-ATP Synthase Axis Fuels NK Cell Antitumor Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Diversity of Bacteria.Progress in molecular and subcellular biology · 2026
    Review
  14. Review
  15. Article
  16. Article
  17. Ornithine lipids fromGut microbes · 2025
    Article
  18. Lessons from the model gut BacteroidalesJournal of bacteriology · 2025
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eric M BrownBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: erbrown@broadinstitute.org.
Emily R TempleBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Sarah JeanfavreBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Julian Avila-PachecoBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Noel TaylorBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Kai LiuBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Phuong N U NguyenBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ahmed M T MohamedBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Panhasith UngBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Rebecca A WalkerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Daniel B GrahamBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
Clary B ClishBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: xavier@molbio.mgh.harvard.edu.

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Identification and Characterization of Microbial Metabolites in ImmunityR01AI172147 · NIAID · BROAD INSTITUTE, INC. · PI Daniel Bartholomew Graham, Ramnik J Xavier · 2022 to 2026
$3.9M
NIAID NIH HHS R01 AI172147NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

Sphingolipids derived from Bacteroides species are associated with changes in host inflammation and metabolic syndrome; however, the signaling mechanisms within host cells are unknown. We utilize outer membrane vesicles (OMVs) from wild-type and sphingolipid-deficient Bacteroides strains to understand how these lipids modulate host inflammation. Characterization of the lipidome of B. thetaiotaomicron OMVs revealed enrichment of dihydroceramide phosphoethanolamine (CerPE). OMVs deliver bacterial sphingolipids into host dendritic and epithelial cells, where a subset of lipids, including CerPE, stably persist. Similarly, B. thetaiotaomicron colonization results in sphingolipid persistence in murine tissues and host lipidome alterations that are not observed with the sphingolipid-deficient strain. OMVs induce a potent, sphingolipid-dependent interleukin-10 (IL-10) anti-inflammatory response in dendritic cells, which depends on mevalonate pathway activation. Adding a CerPE fraction to sphingolipid-deficient OMVs rescued IL-10 secretion, similarly dependent on mevalonate pathway activation. These data highlight the essential roles of sphingolipids in stimulating anti-inflammatory responses mediated by mevalonate pathway induction.

Indexed as

Anti-Inflammatory AgentsBacteroidesBacteroides thetaiotaomicronMevalonic AcidSphingolipidsAnimalsBacteroides InfectionsCeramidesDendritic CellsEpithelial CellsEthanolaminesHumansInflammationInterleukin-10MiceMice, Inbred C57BLAnti-Inflammatory AgentsCeramidesEthanolaminesInterleukin-10Mevalonic AcidphosphorylethanolamineSphingolipidsanti-inflammatory signalingBacteroidesCerPEdendritic cellsIL-10immunometabolismmevalonate pathwaymicrobiomeOMVsouter membrane vesiclessphingolipids

Identifiers

PMID40449488
PMCPMC12169427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.