Evidence map›Paper›PMID 40449486›Full record

ArticleImmunity2025

A CD4

Jubayer Rahman, Jack A Bibby, Parul Singh, Nicolas S Merle, Erin E West, Andrea Bohrer, Katrin Mayer-Barber, Chengyu Liu, Lauren R Brinster, Behdad Afzali and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jubayer RahmanComplement and Inflammation Research Section, NHLBI, NIH, Bethesda, MD 20892, USA. Electronic address: jubayer.rahman@nih.gov.
Jack A BibbyComplement and Inflammation Research Section, NHLBI, NIH, Bethesda, MD 20892, USA.
Parul SinghComplement and Inflammation Research Section, NHLBI, NIH, Bethesda, MD 20892, USA.
Nicolas S MerleComplement and Inflammation Research Section, NHLBI, NIH, Bethesda, MD 20892, USA.
Erin E WestComplement and Inflammation Research Section, NHLBI, NIH, Bethesda, MD 20892, USA.
Andrea BohrerLaboratory of Clinical Infectious Diseases, Inflammation & Innate Immunity Unit, NIAID, NIH, Bethesda, MD 20892, USA.
Katrin Mayer-BarberLaboratory of Clinical Infectious Diseases, Inflammation & Innate Immunity Unit, NIAID, NIH, Bethesda, MD 20892, USA.
Chengyu LiuTransgenic Core, NHLBI/NIH, Bethesda, MD 20892, USA.
Lauren R BrinsterOffice of Research Services, Division of Veterinary Resources, NIH, Bethesda, MD 20892, USA.
Behdad AfzaliImmunoregulation Section, Kidney Diseases Branch, NIDDK, NIH, Bethesda, MD 20892, USA.
Ana M BrionesDepartment of Pharmacology, Faculty of Medicine, Universidad Autónoma de Madrid, Hospital La Paz Institute for Health Research (IdiPaz), CIBER Cardiovascular (CIBERCV), Madrid, Spain.
Sara AlehashemiLaboratory of Clinical Immunology & Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.
Farzana BhuyanLaboratory of Clinical Immunology & Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.
Jiahui GeCardiovascular Research Center, Shantou University Medical College, Shantou, China.
Xijian ChenCardiovascular Research Center, Shantou University Medical College, Shantou, China.
Yingbi ZhouCardiovascular Research Center, Shantou University Medical College, Shantou, China.
Murray C H ClarkeThe University of Cambridge, Heart & Lung Research Institute, Papworth Road, Cambridge Biomedical Campus, Cambridge CB2 0BB, UK.
Bin LiuCardiovascular Research Center, Shantou University Medical College, Shantou, China; Chaoshan Branch of State Key Laboratory for Esophageal Cancer Prevention and Treatment, Shantou University Medical College, Shantou, China.
Raphaela Goldbach-ManskyLaboratory of Clinical Immunology & Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.
C Henrique SerezaniVanderbilt Center for Immunobiology and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Claudia KemperComplement and Inflammation Research Section, NHLBI, NIH, Bethesda, MD 20892, USA. Electronic address: claudia.kemper@nih.gov.

Funding

The role of the intracellular complement system - the complosome - in Th1 biologyZIAHL006223 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KEMPER, CLAUDIA · 2017 to 2025
$16.9M
Neurocognitive and Metabolic Effects of Mild HypothyroidismR01DK075496 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI SAMUELS, MARY H · 2008 to 2012
$2.1M
Prostaglandin E2 Actions and Enhanced Susceptibility to Skin Infection in Diabetic MiceR01DK122147 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEREZANI, C. HENRIQUE · 2020 to 2022
$1.7M
Intramural NIH HHS ZIA HL006223NIDDK NIH HHS R01 DK075496NIDDK NIH HHS R01 DK122147
6 · The paper itself

Abstract

T helper 1 (Th1) cell initiation pathways are well characterized; however, those regulating their contraction are less understood. Here, we define a CD4

Indexed as

CD4-Positive T-LymphocytesEpoprostenolReceptor, Anaphylatoxin C5aTh1 CellsAnimalsDinoprostoneHumansMiceMice, Inbred C57BLMice, KnockoutSignal TransductionDinoprostoneEpoprostenolReceptor, Anaphylatoxin C5aC5aR2CAPScomplementcomplosomeCrohn’s diseasecryopyrin-associated periodic fever syndromeIL-1βprostacyclinprostaglandinrheumatoid arthritisTh1 cell responses

Identifiers

PMID40449486
PMCPMC12302006

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.