Evidence map›Paper›PMID 40449092›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2025

Application of preclinical absorption, distribution, metabolism, elimination in vitro techniques for the characterization and compound library optimization of novel antibiotic gallium salophen.

Samuel A Krug, Aziza Frank, Lucia Hwang, Madison Worth, Kieran Johnson, Christine Rojas, Ludovic Muller, Sarah L J Michel, Angela Wilks, Fengtian Xue and 1 more

Abstract read
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samuel A KrugDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland.
Aziza FrankDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland.
Lucia HwangDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland.
Madison WorthDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland.
Kieran JohnsonDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland.
Christine RojasDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland.
Ludovic MullerDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland.
Sarah L J MichelDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland.
Angela WilksDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland.
Fengtian XueDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland.
Maureen A KaneDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland. Electronic address: mkane@rx.umaryland.edu.

Funding

Mechanistic characterization and regulation of the non-redundant phu and has heme uptake systems of Pseudomonas aeruginosaR01AI134886 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Angela Wilks · 2018 to 2026
$3.0M
Pseudomonas aeruginosa heme sensing inhibitors targeting HasApR21AI161313 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI WILKS, ANGELA, XUE, FENGTIAN · 2021 to 2022
$425k
NIAID NIH HHS R01 AI134886NIAID NIH HHS R21 AI161313
6 · The paper itself

Abstract

Multidrug-resistant pathogens are an emerging threat to public health. Metal-based drugs have shown antimicrobial properties. As a result, metallotherapeutics have an untapped potential to combat antibiotic-resistant infections. Characterization of additional physiochemical attributes is needed to progress metallodrugs in the clinical pipeline. In order to fully characterize a modest library of compounds based on novel therapeutic gallium salophen (GaSal), target binding affinity (dissociation constant, K

Indexed as

Anti-Bacterial AgentsGalliumAnimalsCaco-2 CellsHumansIntestinal AbsorptionMicrosomes, LiverProtein BindingTissue DistributionAnti-Bacterial AgentsGalliumAbsorptionAntibioticdistributioneliminationICP-MSLC-MS/MSmetabolismMetallotherapeuticPseudomonas aeruginosa

Identifiers

PMID40449092
PMCPMC12264554

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.