ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2025
You've got mail: comparing individuals who do and do not provide DNA saliva samples by mail in a study of severe alcohol use disorder.
Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- High Prevalence of Suicidal Behavior in Severe Alcohol Use Disorder Linked to Specific Neurocognitive Deficits: The Cognition, Alcohol, Genes, and Environment Study.Journal of studies on alcohol and drugs · 2026Article
- Participant ascertainment is differentially related to phenotypic characteristics and alcohol-related genetic liability in a sample with severe alcohol use disorder.Alcohol, clinical & experimental research · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveMany genetic studies of psychiatric disorders rely on participants to mail in DNA samples. Differences in who returns a sample may affect the generalizability of these studies, but little attention has focused on possible differences between participants who do and do not provide samples. The present study compared participants with severe lifetime alcohol use disorder (AUD) who did and did not return saliva DNA samples.
methodsN = 3927 individuals were recruited through Facebook for a genome-wide association study of severe AUD. Participants completed an online survey and agreed to provide a saliva DNA sample by mail. Survey measures included: demographics, quantity and frequency of recent alcohol and tobacco use, impulsivity, and personality. Participants who returned the saliva kit (n = 2412) were compared to those who did not provide DNA samples (n = 1515) were compared using univariate Chi-square and t-tests.
resultsThe sample was predominantly White (88.3%) and female (64.0%). DNA providers were more likely than non-providers to report graduate-level education. DNA providers were also less likely to report recent cigarette smoking and scored higher on measures of conscientiousness, perseverance, and premeditation. Using multivariate regression, the most parsimonious model found that being male, a non-smoker, and endorsing perseverance was associated with providing DNA.
conclusionsIn an online sample of individuals with severe AUD, participants who did not provide DNA samples showed multiple demographic and psychosocial differences from those who did provide samples. These findings may have implications for generalizability and suggest that further research is needed.
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