ArticleBulletin of experimental biology and medicine2025
Effect of Metabolites of Vaginal Lactobacilli on Neutrophils Function.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The cervicovaginal gut microbiota axis as a key determinant of systemic physiology.Gut microbes · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the effect of metabolites produced by lactobacilli on the metabolic and killing activities of neutrophil. Treatment with lactic acid at a concentration of 5.6 mM increased dehydrogenase activity and killing activity of neutrophils and slightly decreased the mitochondrial potential in cells; at concentrations of 11.1 and 22.2 mM, lactate decreased dehydrogenase activity, which was accompanied by a decrease in the mitochondrial potential in cells; at a concentration of 11.1 mM, lactate decreased killing activity of neutrophils. Hydrogen peroxide increased the dehydrogenase and killing activities at concentrations of 0.59 and 2.36 mM and decreased these parameters at a concentration of 1.18 mM; these changes were accompanied by a decrease in the number of cells with high mitochondrial potential. It is assumed that the ability of vaginal lactobacilli to modulate neutrophil activity has important evolutionary significance and allows regulating the number of opportunistic microorganisms.
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Registered trials
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