Alternative Combinations of IL17A Polymorphic Variants with the Variants of TNF, IL1B, IL6, and IL8 Proinflammatory Cytokines Genes in Uterine Leiomyoma.

V I Konenkov, V F Prokofiev, A V Shevchenko, E G Koroleva, Yu S Timofeeva, S V Aidagulova, I O Marinkin

Abstract read

In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

V I KonenkovResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

V F ProkofievResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. vf_prok@mail.ru.

A V ShevchenkoResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

E G KorolevaNovosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.

Yu S TimofeevaNovosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.

S V AidagulovaNovosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.

I O MarinkinNovosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic analysis of DNA samples from 180 patients with uterine leiomyoma (UL) and 98 women of the control group without UL showed that the frequency of homozygous AA variant of IL17A -197G/A gene polymorphism was significantly increased in UL (odds ratio, OR = 4.33; p = 0.0096). The frequency of this variant was even more increased when it is combined with homozygote variants GG at positions 238 and 308 of the TNF gene. The combination of the genotypes of these polymorphisms in the AA-GG-GG positions is not only widespread among patients with UL (OR = 12.22; p = 0.0054), but also was not detected in the control group. On the contrary, heterozygous IL17A -197 GA in combination with TNF-863C/A, TNF-308G/A, TNF-238G/A, IL1B-31T/C, IL6-174C/G, and IL8-251T/A are detected significantly less frequently among patients with UL than in the control, with taking into account Bonferroni's correction for the multiplicity of comparisons. The results obtained can be used in the personalized prognosis of predisposition to UL.

Indexed as

Interleukin-17Interleukin-1betaInterleukin-6Interleukin-8LeiomyomaTumor Necrosis Factor-alphaUterine NeoplasmsAdultCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansInterleukin-18Middle AgedCXCL8 protein, humanIL17A protein, humanIL18 protein, humanIL1B protein, humanIL6 protein, humanInterleukin-17Interleukin-18Interleukin-1betaInterleukin-6Interleukin-8TNF protein, humanTumor Necrosis Factor-alphaand IL8 combined genotypesIL1BIL6TNFuterine leiomyoma; single nucleotide polymorphism; IL17A

Identifiers

PMID40448881

DOI10.5021/ad.2012.24.1.61

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.