Observational studySleep & breathing = Schlaf & Atmung2025
High-sensitivity C-reactive protein as a mediator between sleep quality and mental health in first-degree relatives of individuals with schizophrenia.
Observational study in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
objectiveThis study investigates the mediating role of high-sensitivity C-reactive protein (hs-CRP) in the relationship between sleep quality and mental health in first-degree relatives of individuals with schizophrenia.
methodsA total of 150 first-degree relatives of schizophrenia patients were recruited for this cross-sectional, observational study. Based on their Pittsburgh Sleep Quality Index (PSQI) scores, participants were divided into two groups: the Good Sleep Quality Group (GSQG, n = 77) and the Poor Sleep Quality Group (PSQG, n = 73).
resultsIn the GSQG, mean arterial pressure (MAP), fasting blood glucose (FBG), uric acid (UA), hs-CRP (P < 0.05), and body mass index (BMI), heart rate (HR) (P < 0.01) were significantly lower than in the PSQG. The number of individuals with abnormal mental health conditions (AMHC) in the GSQG was also significantly lower (P < 0.01) compared to the PSQG. For every 1-point increase in PSQI score, hs-CRP levels significantly increased by 0.177 mg/L (P < 0.001) after adjusting for sex, age, MAP, BMI, HR, FBG, HDL, LDL, triglycerides (TG), UA, smoking, and alcohol consumption. The Positive Symptom Total (PST) score increased significantly by 0.336 (P < 0.01) or 0.337 (P < 0.05) due to the mediating effect of hs-CRP in the crude model, and 0.035 after adjustment for the aforementioned covariates (P < 0.05).
conclusionThe findings suggest that hs-CRP may mediate the relationship between poor sleep quality and mental health outcomes in this population.
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