Evidence map›Paper›PMID 40448864›Full record

ReviewMolecular biology reports2025

The multifaceted roles of exosomes in corneal biology: elucidation of underlying mechanisms and therapeutic applications.

Samaneh Ahmadi, Sahar Gohari-Lasaki, Negin Jahangiri, Mahsa Ejlalidiz, Mohammadreza Saberiyan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samaneh Ahmadi *Department of Medical Genetics, Faculty of Medicine, School of Medical Sciences, Hormozgan University of Medical Sciences, P.O.Box: 7919693116, Bandar Abbas, Iran.ORCID https://orcid.org/0000-0002-6926-1351
Sahar Gohari-Lasaki *Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0009-0008-5128-8688
Negin JahangiriDepartment of Biology, Faculty of Basic Sciences and Engineering, Gonbad Kavous University, Gonbad Kavous, Iran.ORCID https://orcid.org/0009-0003-3689-9302
Mahsa EjlalidizMedical Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mahsaejlalidiz@gmail.com.ORCID https://orcid.org/0000-0001-7043-1533
Mohammadreza SaberiyanDepartment of Medical Genetics, Faculty of Medicine, School of Medical Sciences, Hormozgan University of Medical Sciences, P.O.Box: 7919693116, Bandar Abbas, Iran. saberiyanmr@gmail.com.ORCID https://orcid.org/0000-0001-6343-8518

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cornea, as the essential part of the eye with the duty of maintaining transparency and vision, is susceptible to various diseases and genetic abnormalities. Vision loss due to corneal disorders is a global concern, prompting research into innovative treatment approaches. The investigations have provided a significant role that exosomes play in maintaining corneal homeostasis and promoting intercellular communication. The cornea is made up of cellular and acellular components. The cellular components include the epithelial cells, stromal keratocytes, and endothelial cells, which secrete exosomes that contribute to preserving corneal transparency, immune privilege, and tissue repair. These nanosized vesicles contain molecules that regulate immune responses, promote cell proliferation and migration, and protect against stress-induced cell death. In this review, we try to survey the therapeutic potential and effects of exosomes in treating various corneal conditions, which can contribute to enhance corneal healing, reduce scarring, and improve visual outcomes.

Indexed as

CorneaCorneal DiseasesExosomesAnimalsHumansWound HealingCorneal disordersExosomesTissue repairVision loss

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.