Evidence map›Paper›PMID 40448861›Full record

Trial reportDysphagia2025

Repetitive Transcranial Magnetic Stimulation Over a Different Side of the Cortex for Rehabilitating Poststroke Dysphagia: A Randomized, Double-blind Clinical Trial.

Zhongli Wang, Jianming Fu, Chun Yang, Yunhai Yao, Keren He, Xiaolin Sun, Yun Ren, Minmin Jin, Danni Xu, Lei Yang and 3 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Dysphagia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhongli Wang *Department of Rehabilitation Medicine, The Second Hospital of Jiaxing City, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang Province, China.
Jianming Fu *Department of Rehabilitation Medicine, The Second Hospital of Jiaxing City, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang Province, China.
Chun Yang *School of Public Health, Capital Medical University, Beijing, 10069, China.
Yunhai YaoDepartment of Rehabilitation Medicine, The Second Hospital of Jiaxing City, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang Province, China.
Keren HeDepartment of Rehabilitation Medicine, The Second Hospital of Jiaxing City, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang Province, China.
Xiaolin SunDepartment of Rehabilitation Medicine, The Second Hospital of Jiaxing City, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang Province, China.
Yun RenDepartment of Rehabilitation Medicine, The Second Hospital of Jiaxing City, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang Province, China.
Minmin JinDepartment of Rehabilitation Medicine, The Second Hospital of Jiaxing City, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang Province, China.
Danni XuDepartment of Rehabilitation Medicine, The Second Hospital of Jiaxing City, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang Province, China.
Lei YangZhejiang Chain Forensic Science Jiaxing Xinlian Center, Jiaxing, 314000, Zhejiang Province, China.
Wei WangDepartment of Rehabilitation, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, Liaoning, China.
Ming ZengDepartment of Rehabilitation Medicine, The Second Hospital of Jiaxing City, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang Province, China. zengming@zjxu.edu.cn.
Xudong GuDepartment of Rehabilitation Medicine, The Second Hospital of Jiaxing City, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang Province, China. jxgxd@hotmail.com.

Funding

Jiaxing Science and Technology Plan Project 2023AD11020Zhejiang Basic Public Welfare Research Project LGF21H17003Zhejiang Provincial Medical and Health Science and Technology Project 2022KY1252Zhejiang Provincial Medical and Health Science and Technology Project 2022KY378Zhejiang Provincial Medical and Health Science and Technology Project 2022KY383Zhejiang Provincial Natural Science Foundation LGF19H17001
6 · The paper itself

Abstract

objectiveThis randomized, sham-controlled, double-blind study investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on both bilateral and unilateral brain regions in patients with poststroke dysphagia.

methodsSeventy poststroke dysphagia patients were randomly divided into four intervention groups: the ipsilesional stimulation group (ISG), the contralesional stimulation group (CSG), the bilateral stimulation group (BSG), and the sham stimulation group (SSG) with 3 Hz rTMS administered for 4 weeks, five days per week. Outcomes were assessed using a videofluoroscopic swallowing study (VFSS) at three time points: at baseline before the intervention (T0), immediately after the intervention (T1), and four weeks after intervention cessation (T2). These assessments included the latency of wave V in brainstem auditory evoked potentials (BAEP), Dysphagia Outcome and Severity Scale (DOSS), Penetration and Aspiration Scale (PAS), and Videofluoroscopic Dysphagia Scale (VDS).

resultsThe swallowing improvement of BSG and CSG were showed significantly greater than SSG (p < 0.05), while the ISG exhibited no significant differences in the DOSS and total VDS scores (p > 0.05). Furthermore, some sub-items of the VDS were lower than those in the SSG (p < 0.05). The latency of wave V in BAEP of ipsilesional and contralesional was synchronized and shortened in the BSG at T1 and T2; similar results were observed in the CSG at T2. In contrast, in the ISG, only the latency of ipsilesional V was shortened at T1 and T2 (p < 0.05).

conclusionsThe results of the present study provide evidence that 3 Hz rTMS is more effective than traditional dysphagia therapies when applied to the bilateral and contralesional motor cortices, especially bilaterally over the cortical areas projecting to the mylohyoid muscles. Functional recovery was observed after real rTMS compared to the SSG, with the effects persisting at T2.

trial registrationStudy on the imaging of swallowing function and multimodal brain function in stroke patients with dysphagia based on different lateral repetitive transcranial magnetic stimulation: a randomized controlled trial. ( http://www.chictr.org.cn/ , ChiCTR2100044993, April 3, 2021).

Indexed as

Deglutition DisordersStrokeStroke RehabilitationTranscranial Magnetic StimulationAgedDeglutitionDouble-Blind MethodFemaleHumansMaleMiddle AgedTreatment OutcomeBrainstem Auditory Evoked PotentialsDeglutitionDysphagiaRepetitive Transcranial Magnetic StimulationStroke

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.