Evidence map›Paper›PMID 40448849›Full record

ArticleMikrochimica acta2025

An all-in-one MnO₂-DNA assembly nanoplatform for imaging, detection, and gene-chemodynamic combination therapy of MCF-7 cells.

Ruyan Zhang, Zhiqing Zhang, Guodong Zhang, Jingyun Zhuang, Xiaobing Huo, Gan Ning, Tianxin Weng, Xiufeng Wang, Ting Zhou, Fang Wang

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruyan Zhang *College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, China.
Zhiqing Zhang *College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, China. zhangzq@upc.edu.cn.
Guodong ZhangCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, China.
Jingyun ZhuangCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, China.
Xiaobing HuoCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, China.
Gan NingCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, China.
Tianxin WengCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, China.
Xiufeng WangCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, China.
Ting ZhouCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, China.
Fang WangCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, China. wangfang@upc.edu.cn.

Funding

Fundamental Research Funds for the Central Universities 22CX03024AGraduate Education Reform Project SDYAL2024044Natural Science Foundation of Shandong Province ZR2022MB148
6 · The paper itself

Abstract

A nano-theranostic system is reported that integrates imaging, detection, and treatment. The DNA assembly self-assembled by rolling circle amplification (RCA) product and four oligonucleotides are combined with MnO₂ nanosheets to construct DNA assembly@MnO₂. One repeat unit of the DNA assembly contains an aptamer module for specific targeting, a metal ion-activated intracellular imaging module, and a DNAzyme module for gene therapy (GT). Upon entering cancer cells, MnO₂ nanosheets are reduced to Mn

Indexed as

DNAManganese CompoundsOxidesAptamers, NucleotideDNA, CatalyticGenetic TherapyGlutathioneHumansMCF-7 CellsAptamers, NucleotideDNADNA, CatalyticGlutathioneManganese Compoundsmanganese dioxidemanganese oxideOxidesChemodynamic therapyDNAzymeGene therapyMnO₂ nanosheetsRolling circle amplification

Identifiers

PMID40448849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.