Relationship between spleen volume and diameter for assessment of response to treatment on CT in patients with hematologic malignancies enrolled in clinical trials.

Kyle A Hasenstab, Jie Lu, Lambert T Leong, Emily Bossard, Evye Pylarinou-Sinclair, Karthika Devi, Guilherme M Cunha

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Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Kyle A HasenstabDepartment of Mathematics and Statistics, San Diego State University, San Diego, USA.

Jie LuOncoRad Research Core, Department of Radiology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.

Lambert T LeongOncoRad Research Core, Department of Radiology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.

Emily BossardOncoRad Research Core, Department of Radiology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.

Evye Pylarinou-SinclairOncoRad Research Core, Department of Radiology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.

Karthika DeviOncoRad Research Core, Department of Radiology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.

Guilherme M CunhaOncoRad Research Core, Department of Radiology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA. gcunha@uw.edu.

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6 · The paper itself

Abstract

purposeInvestigate spleen diameter (d) and volume (v) relationship in patients with hematologic malignancies (HM) by determining volumetric thresholds that best correlate to established diameter thresholds for assessing response to treatment. Exploratorily, interrogate the impact of volumetric measurements in response categories and as a predictor of response.

methodsSecondary analysis of prospectively collected clinical trial data of 382 patients with HM. Spleen diameters were computed following Lugano criteria and volumes using deep learning segmentation. d and v relationship was estimated using power regression model, volumetric thresholds ([Formula: see text]) for treatment response estimated; threshold search to determine percentual change ([Formula: see text] and minimum volumetric increase ([Formula: see text]) that maximize agreement with Lugano criteria performed. Spleen diameter and volume predictive performance for clinical response investigated using random forest model.

results[Formula: see text] describes the relationship between spleen diameter and volume. [Formula: see text] for splenomegaly was 546 cm³. [Formula: see text], [Formula: see text], and [Formula: see text] for assessing response resulting in highest agreement with Lugano criteria were 570 cm

conclusionThis study provides empirical spleen volume threshold and percentual changes that best correlate with diameter thresholds, i.e., Lugano criteria, for assessment of response to treatment in patients with HM. In our dataset use of spleen volumetric thresholds versus diameter thresholds resulted in similar response assessment categories and did not signal differences in predictive values for response.

Indexed as

Hematologic NeoplasmsSpleenTomography, X-Ray ComputedAdultAgedClinical Trials as TopicFemaleHumansMaleMiddle AgedOrgan SizeProspective StudiesTreatment OutcomeComputer tomographyHematologic malignanciesResponse assessmentSpleen

Identifiers

PMID40448843

DOI10.1007/s10278-020-00398-y

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.