Evidence map›Paper›PMID 40448842›Full record

ArticleWorld journal of urology2025

The effect of indwelling duration of ureteral stent on the formation and pathological characteristics of ureteral stricture after holmium laser thermal injury.

Chao Li, Hao Dong, Rui Yang, Zhaoxin Ying, Shuwei Zhang, Minjie Chen, Yonghan Peng, Xiaofeng Gao

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Article in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chao Li *Department of Urology, Changhai Hospital, First Affiliated Hospital of Naval Medical University, Shanghai, China.
Hao Dong *Department of Urology, Changhai Hospital, First Affiliated Hospital of Naval Medical University, Shanghai, China.
Rui Yang *Department of Urology, Changhai Hospital, First Affiliated Hospital of Naval Medical University, Shanghai, China.
Zhaoxin YingDepartment of Urology, Changhai Hospital, First Affiliated Hospital of Naval Medical University, Shanghai, China.
Shuwei ZhangDepartment of Urology, Changhai Hospital, First Affiliated Hospital of Naval Medical University, Shanghai, China.
Minjie ChenDepartment of Urology, Changhai Hospital, First Affiliated Hospital of Naval Medical University, Shanghai, China.
Yonghan PengDepartment of Urology, Changhai Hospital, First Affiliated Hospital of Naval Medical University, Shanghai, China. yonghanyhtl@163.com.
Xiaofeng GaoDepartment of Urology, Changhai Hospital, First Affiliated Hospital of Naval Medical University, Shanghai, China. gxfdoc@sina.com.

Funding

National Natural Science Foundation of China 82270805
6 · The paper itself

Abstract

objectiveA porcine model was established to investigate the effect of indwelling duration of ureteral stents on formation and pathological characteristics of ureteral stricture after laser thermal injury.

methodsPigs were randomly divided into 2 groups, A and B, with 15 pigs in each group. Holmium laser was used to cauterize the bilateral ureters at 5, 10, 15, and 20 cm from the Ureteropelvic Junction. Ureteral stents were indwelled for 4 weeks in Group A and 10 weeks in Group B. Ureteroscopy was performed 3 months after stents removal. Pigs were sacrificed to detect the damage point stricture. The cauterization tissue was harvested for pathological analysis.

resultsGroup A included 13 pigs and group B included 14 pigs. The incidence of ureteral stricture in group A was higher than that in group B (P < 0.001). The percentages of inflammatory cell infiltration (P = 0.001), epithelial necrosis (P < 0.001), and epithelial hyperplasia (P < 0.001) were higher in Group A than in Group B. The proportion of muscle necrosis in Group A was lower than in Group B (P < 0.001). The percentage of the fibrosis area in group A was lower than that in group B (P = 0.001).

conclusionCompared with 4 weeks, 10 weeks of ureteral stent placement after laser thermal injury can reduce the risk of ureteral stricture, but may increase the risk of ureteral muscularis cell damage and tissue fibrosis. However, further clinical studies and animal experiments are required to confirm our results.

Indexed as

Lasers, Solid-StateStentsUreterUreteral ObstructionAnimalsConstriction, PathologicDisease Models, AnimalRandom AllocationSwineTime FactorsUreteroscopyAnimal modelPathological characteristicsThermal injuryUreteral stentUreteral stricture

Identifiers

PMID40448842

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.