Evidence map›Paper›PMID 40448820›Full record

ReviewInflammopharmacology2025

The therapeutic mechanisms of quercetin on inflammatory diseases: an update.

Jie Xu, Haikun Hu, Haixu Jiang, Qiuzhu Wei, Honglin Zhang, Qingyi Lu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jie Xu *School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China.
Haikun Hu *School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China.
Haixu Jiang *School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China.
Qiuzhu WeiSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China.
Honglin ZhangSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China.
Qingyi LuSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. lu_qingyi@126.com.ORCID http://orcid.org/0000-0003-0738-8725

Funding

National Natural Science Foundation of China 82205068Research Program from Beijing University of Chinese Medicine 2021-JYB-XJSJJ-023Research Program from Beijing University of Chinese Medicine 2023-JYB-JBQN-019
6 · The paper itself

Abstract

Bioactive compounds derived from medicinal plants have become a significant source of drugs for inflammatory diseases treatment, particularly those caused by immune system abnormalities. Quercetin, a flavonol found in a wide variety of herbs, fruits, and vegetables, has garnered attention for its diverse biological properties, including anti-inflammatory, anticancer, and antiviral activities. Numerous in vivo and ex vivo studies have validated quercetin's role in treating inflammatory diseases through multiple pathways, mainly involving anti-oxidative stress, modulation of metabolism, intestinal flora, apoptosis, endoplasmic reticulum stress, and macrophage polarization, indicating it a promising pharmaceutical candidate for managing inflammatory and autoimmune conditions. We aimed to systematically review quercetin's anti-inflammatory activity and the mechanisms of action across various inflammatory diseases in the digestive, respiratory, endocrine, neurological, and osteoarticular systems. By summarizing the therapeutic potential of quercetin in these multifaceted conditions, this review seeks to provide a solid foundation for future clinical research and application strategies involving quercetin.

Indexed as

Anti-Inflammatory AgentsInflammationQuercetinAnimalsAntioxidantsHumansOxidative StressAnti-Inflammatory AgentsAntioxidantsQuercetinAnti-inflammationAnti-oxidative stressInflammatory diseasesQuercetin

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.