Evidence map›Paper›PMID 40448801›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2025

Analysis of the mechanism of tripropylamine-enhanced lycopene accumulation in Blakeslea trispora through transcriptome.

Aizhong Han, Yue Liu, Ziang Gao, Jinghan Wang, Tianxiang Zhang, Ruigang Zhang, Gongzhan Sun, Yanlong Wang

Abstract read
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In one paragraph

Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aizhong HanLin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical University, Jining, China.
Yue LiuLin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical University, Jining, China.
Ziang GaoLin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical University, Jining, China.
Jinghan WangLin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical University, Jining, China.
Tianxiang ZhangLin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical University, Jining, China.
Ruigang ZhangLin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical University, Jining, China.
Gongzhan SunLin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical University, Jining, China.
Yanlong WangLin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical University, Jining, China. wangyanlong0000@126.com.

Funding

College Students' Innovative Entrepreneurial Training Plan Program of Jining Medical University cx2023023zLin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University JYHL2021MS15Natural Science Foundation of Shandong Province ZR2021QC148
6 · The paper itself

Abstract

Lycopene is a carotenoid with strong antioxidant properties. Treatment with tripropylamine (TPA) greatly increases lycopene production by Blakeslea trispora, but the mechanism of this effect remains unclear. In this study, a reference-free transcriptome was used to analyze changes in gene expression in B. trispora after treatment with TPA. Downregulated genes were mostly involved in primary and secondary metabolic pathways, whereas upregulated genes were mostly related to autophagy and nucleotide excision repair. In addition, after TPA treatment, the mycelium swelling and the number of spores decreased. Our study suggests that TPA causes DNA damage, which upregulates the expression of nucleotide excision repair genes Xpb, Xpg, Csb, Polr2, and genome stability regulator gene Rmi1, as well as downregulation of Lsm2 and Dars2 and upregulation of G10, which are related to mRNA spliceosomes, leaving the cell in a state of starvation and triggering lysosomal-, peroxisomal-, and vacuole-autophagy. The autophagosome recycles material from spores, reduces spore production, and induces mycelial swelling, which, in turn, increases lycopene production and storage.

Indexed as

LycopeneMucoralesTranscriptomeDNA DamageFungal ProteinsGene Expression ProfilingGene Expression Regulation, FungalMyceliumSpores, FungalFungal ProteinsLycopeneAutophagyBlakeslea trisporaLycopeneReference-free transcriptomeTripropylamine

Identifiers

PMID40448801

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.