Evidence map›Paper›PMID 40448761›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation.

Soraia P Caetano-Silva, Neil Marr, Simon C F Rawlinson, Andrew A Pitsillides

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Soraia P Caetano-SilvaGreat Ormond Street Institute of Child Health, Zayed Centre for Research into Rare Disease in Children, University College of London, London, UK.
Neil MarrSkeletal Biology Group, Comparative Biomedical Sciences, The Royal Veterinary College, London, UK.
Simon C F RawlinsonQueen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry, London, UK.
Andrew A PitsillidesSkeletal Biology Group, Comparative Biomedical Sciences, The Royal Veterinary College, London, UK. apitsillides@rvc.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The techniques that are useful for applying mechanical strain to bone and bone cells are now more diverse than described in the second edition. Their output has also increased substantially and, perhaps most importantly, their significance is now broadly accepted. This growth in the use of methods for applying mechanical strain to bone and its constituent cells and increased awareness of the importance of the mechanical environment in controlling normal bone cell behavior has indeed heralded new therapeutic approaches. We have expanded the text to include additions and modifications made to the straining apparatus and updated the research cited to support this growing role of cell cultures, including co-culture systems and primary cells, tissue engineering, and organ culture models to analyze responses of bone cells to mechanical stimulation. We understand that there are approaches not covered here and appreciate that alternative strategies have their own value and utility.

Indexed as

Bone and BonesCell Culture TechniquesOsteoblastsOsteocytesStress, MechanicalAnimalsCells, CulturedCoculture TechniquesHumansOrgan Culture TechniquesTissue EngineeringMechanical loadingOrgan cultureStrain

Identifiers

PMID40448761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.