Evidence map›Paper›PMID 40448739›Full record

SynthesisSleep & breathing = Schlaf & Atmung2025

Efficacy and safety of TCM non-pharmacologic therapy for post-stroke insomnia: a systematic review and network meta-analysis.

Wenyu Liu, Ruizhi Jing

Abstract readNetwork Meta-AnalysisSystematic Review
In one paragraph

Synthesis in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Wenyu LiuShaoxing Keqiao District Traditional Chinese Medcine Hospital Medical Community General Hospital, Shaoxing, 312000, China.
Ruizhi JingShaoxing Keqiao District Traditional Chinese Medcine Hospital Medical Community General Hospital, Shaoxing, 312000, China. yanchenliu311322@foxmail.com.

Funding

Zhejiang Traditional Chinese Medicine Administration 2023ZL736
6 · The paper itself

Abstract

backgroundPost-stroke insomnia is a common and frequently occurring disease that has a significant impact on the quality of life of patients. TCM (traditional Chinese medicine) non-pharmacologic therapy is increasingly being used for patients with post-stroke insomnia. The purpose of this study is to evaluate the efficacy and safety of the TCM non-pharmacologic therapy for post-stroke insomnia.

methodsEnglish and Chinese databases, including PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wanfang, VIP, and SinoMed were retrieved to collect randomized controlled trials (RCTs) comparing the TCM non-pharmacologic therapy with Western medicine in the treatment of post-stroke insomnia. The search was conducted until March 26, 2024. Data analysis was conducted using Stata15.0.

resultsThis study included a total of 60 RCTs, involving 5 TCM non-pharmacologic therapies and 4,587 patients. The results of the network meta-analysis unveiled that Western medicine combined with massage (SUCRA93.8), Western medicine combined with auricular point sticking (SUCRA80.5), and needle embedding (SUCRA71.5) were the top three measures in clinical efficacy. For improving the Pittsburgh Sleep Quality Index (PSQI), massage (SUCRA86.1) was the most effective, followed by Western medicine combined with auricular point sticking (SUCRA85.4), and Western medicine combined with needle embedding (SUCRA66.4). Regarding adverse reactions, the top three interventions were traditional acupuncture (SUCRA87.7), moxibustion (SUCRA63.2), and Western medicine combined with traditional acupuncture (SUCRA46.0).

conclusionsTCM non-pharmacologic therapy and Western medicine combined with TCM non-pharmacologic therapy can improve clinical efficacy in post-stroke insomnia, enhance sleep quality, and reduce adverse reactions. Due to the limitations of the included studies, the methodological quality is generally not high, and multicenter, large sample, high-quality RCTs are still needed for validation in the future.

Indexed as

Medicine, Chinese TraditionalSleep Initiation and Maintenance DisordersStrokeHumansRandomized Controlled Trials as TopicTreatment OutcomeMoxibustionNeedle embeddingNetwork meta-analysisPost-stroke insomniaTCM non-pharmacologic therapyTraditional acupuncture

Identifiers

PMID40448739
PMCPMC12126364

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.