Evidence map›Paper›PMID 40448736›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Adaption and validation of a glomerular filtration rate estimation equation for Chinese children: a cross-sectional analysis of pooled data.

Ruohua Yan, Xiaowen Wang, Chao Zhang, Chen Wang, Yaguang Peng, Lin Huang, Hans Pottel, Fang Wang, Xiaoxia Peng

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ruohua YanCenter for Clinical Epidemiology and Evidence-Based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Xiaowen WangDepartment of Nephrology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chao ZhangCenter for Clinical Epidemiology and Evidence-Based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Chen WangOutpatient Department, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Yaguang PengCenter for Clinical Epidemiology and Evidence-Based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Lin HuangDepartment of Nephrology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hans PottelDepartment of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.
Fang WangDepartment of Nuclear Medicine, Medical Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 663wf2019@sina.com.
Xiaoxia PengCenter for Clinical Epidemiology and Evidence-Based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. pengxiaoxia@bch.com.cn.ORCID 0000-0001-8789-469X

Funding

Beijing Nova Program Z211100002121053
6 · The paper itself

Abstract

backgroundThis study aimed to adapt the existing Q-based equation for glomerular filtration rate (GFR) estimation using serum creatinine (SCr) to Chinese children by modification of certain parameters, and to establish the pediatric reference intervals (RIs) for estimated GFR in China accordingly.

methodsThe Q-based equation had the form eGFR = M/(SCr/Q), where the parameter M was estimated from 328 children with measured GFR in Wuhan Children's Hospital, and the parameter Q was fitted among 11,713 healthy children volunteers who had SCr recruited from 11 provinces of China. The Q-based equation was applied to 60,524 inpatients in Beijing Children's Hospital to assess the impact of estimated GFR on the clinical diagnosis of acute kidney injury (AKI). Then, the Q-based equation was used to estimate GFR in a large representative population of healthy Chinese children for RI establishment.

resultsThe parameter M was estimated separately in children aged less than 2 years (100.2) and 2 years or above (107.3). The parameter Q was modeled as a linear function of age in boys (19.5 + 3.2Age) and girls (23.6 + 2.2Age), respectively. The GFR estimated by the Q-based equation could well identify AKI, with a significantly higher risk of in-hospital mortality in AKI patients than non-AKI patients (OR, 5.69; 95% CI, 4.80-6.74). The RI of estimated GFR for children aged 2 years or above ranged from 82.5 to 145.2 ml/min/1.73 m

conclusionsThe Q-based equation is simple and practical for GFR estimation in Chinese children.

Indexed as

Acute Kidney InjuryCreatinineGlomerular Filtration RateAdolescentChildChild, PreschoolChinaCross-Sectional StudiesEast Asian PeopleFemaleHumansInfantMaleReference ValuesCreatinineChildrenEquationGlomerular filtration rateSerum creatinine

Identifiers

PMID40448736

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