ArticleArchives of gynecology and obstetrics2025
Impact of trophectoderm biopsy on serum β-hCG dynamics: PGT cycles vs. non-PGT cycles.
Article in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Molecular Crosstalk Between Intrauterine hCG and Endometrial Receptivity: Signalling Pathways, Immune Modulation, and Translational Perspectives in IVF.International journal of molecular sciences · 2025Review
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Authors and funding
4 authors.
Funding
Abstract
purposePre-implantation genetic testing (PGT), which involves trophectoderm (TE) biopsy, is commonly used to detect genetic abnormalities in embryos. However, its impact on serum β-human chorionic gonadotropin (β-hCG) levels in early pregnancy remains a topic of debate. This study evaluated the effects of TE biopsy on β-hCG dynamics. Serum β-hCG levels on days 9 and 11 post-blastocyst transfer were compared between PGT and non-PGT cycles. Additionally, β-hCG thresholds were explored as potential prognostic markers for success in assisted reproductive technology (ART).
methodsThis retrospective cohort study was conducted at the Memorial Şişli Hospital, İstanbul, Türkiye, between January 2012 and January 2021. The patients undergoing frozen-thawed single blastocyst transfer were divided into PGT (1698 cycles) and non-PGT (1830 cycles) groups. The serum β-hCG levels on days 9 and 11 after embryo transfer (ET) and the rate of β-hCG increase were compared.
resultsIn both groups, higher baseline β-hCG levels and rates of increase were correlated with live birth outcomes than with clinical or biochemical pregnancy loss (p < 0.001). PGT cycles showed lower baseline β-hCG levels across all pregnancy outcomes, but no significant difference in β-hCG increase rates (p > 0.05). After adjusting for confounding factors, PGT cycles were not found to be significantly associated with β-hCG levels.
conclusionSerum β-hCG dynamics strongly predict live birth and clinical pregnancy. PGT did not significantly affect β-hCG levels after adjustment for confounders.
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