Evidence map›Paper›PMID 40448713›Full record

ArticleBrain topography2025

Understanding Sarcasm's Neural Correlates Through a Novel fMRI Spanish Paradigm.

Nicolás Vassolo, Pablo Joaquín Ocampo, Bautista Elizalde Acevedo, Sofía Bosch, Mariana Bendersky, Lucía Alba-Ferrara

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Article in Brain topography, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicolás VassoloUnidad Ejecutora para el Estudio de las Neurociencias y Sistemas Complejos (ENyS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. nvassolo@mail.austral.edu.ar.ORCID 0009-0001-6961-1278
Pablo Joaquín OcampoUnidad Ejecutora para el Estudio de las Neurociencias y Sistemas Complejos (ENyS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Bautista Elizalde AcevedoUnidad Ejecutora para el Estudio de las Neurociencias y Sistemas Complejos (ENyS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Sofía BoschUnidad Ejecutora para el Estudio de las Neurociencias y Sistemas Complejos (ENyS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Mariana BenderskyLaboratorio de Anatomía Viviente, 3ra Cátedra de Anatomía Normal, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Lucía Alba-FerraraUnidad Ejecutora para el Estudio de las Neurociencias y Sistemas Complejos (ENyS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is growing interest in the neural network of pragmatic language and its potential overlap with the Theory of Mind (ToM) network. However, no Spanish-adapted fMRI tasks were used for studying sarcasm, the subtype of pragmatic language most related to ToM. Furthermore, stimuli used in prior studies often impose high cognitive demands, confounding its sarcasm brain representation with the executive network. We investigate the neural correlates of sarcasm in Spanish using a novel experimental paradigm designed to minimize cognitive load and enhance ecological validity. Eighteen healthy, right-handed participants underwent a 3T fMRI session with a sarcasm comprehension task. Brain activations analysed with SPM12 were calculated for sarcasm vs. literal contrast. Sarcasm activated the left temporo-parietal junction, Medial Prefrontal Cortex (BA 10), Left Inferior Frontal Gyrus (BA 45), Left Medial and Superior Temporal Gyrus (BA 21 & 22), and Left Temporal Pole (BA 38). Sarcasm comprehension involves an extensive fronto-temporal-parietal network, with prominent activation of ToM-related areas. These findings suggest an overlap between sarcasm and ToM networks, emphasizing the role of the medial prefrontal cortex in pragmatic language, the left inferior frontal gyrus in semantic integration, and the role of a left-lateralized frontotemporal network for sarcasm processing.

Indexed as

BrainComprehensionLanguageTheory of MindAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleYoung AdultLanguageNetworkNeuroimageNon-literalPragmaticToM

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.