Evidence map›Paper›PMID 40448705›Full record

Trial reportThe Journal of physiology2025

The impact of metformin on placental ageing in humans and mice.

Grace J Hattersley, Liu Yang, Jane L Tarry-Adkins, Antonia Hufnagel, Kwun Kiu Wong, Denise S Fernandez-Twinn, Maria Chukanova, India G Robinson, Amanda J Drake, Rebecca M Reynolds and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Grace J HattersleyUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
Liu YangCentre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Jane L Tarry-AdkinsDepartment of Obstetrics and Gynaecology, the Rosie Hospital and NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.
Antonia HufnagelInstitute of Metabolic Science - Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Kwun Kiu WongInstitute of Metabolic Science - Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6378-3434
Denise S Fernandez-TwinnInstitute of Metabolic Science - Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Maria ChukanovaDepartment of Obstetrics and Gynaecology, the Rosie Hospital and NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.
India G RobinsonUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
Amanda J DrakeCentre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Rebecca M ReynoldsCentre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Susan E OzanneInstitute of Metabolic Science - Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Catherine E AikenDepartment of Obstetrics and Gynaecology, the Rosie Hospital and NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.

Funding

British Heart Foundation PG/20/11/34957British Heart Foundation RE/18/5/34216British Heart Foundation RG/17/12/33167Medical Research Council MC_UU_00014/4Medical Research Council MC_UU_00039Medical Research Council MR/R014167/1Medical Research Council MR/T016701/1NIHR Cambridge Biomedical Research Centre 146281Wellcome TrustWellcome Trust 208363/Z/17/ZWellcome Trust 226800/Z/22/Z
6 · The paper itself

Abstract

Placental ageing refers to the physiological accumulation of a senescent phenotype over a healthy pregnancy. In pregnancies affected by complications such as pre-eclampsia and fetal growth restriction, placental ageing is notably accelerated and observed at an earlier gestational age. Metformin is used during pregnancy for an increasing variety of indications, including treatment of gestational diabetes, and may have a role in slowing cellular ageing. It is therefore essential to understand the potential impact of metformin on placental ageing. Placental samples (n = 105) were obtained from women with body mass index ≥30 kg/m

Indexed as

Cellular SenescenceHypoglycemic AgentsMetforminPlacentaAdultAnimalsDiabetes, GestationalDNA MethylationFemaleHumansMicePregnancyTrophoblastsHypoglycemic AgentsMetforminfetusgestational diabetesmetforminplacentapregnancytrophoblast

Identifiers

PMID40448705
PMCPMC12148204

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.