ArticleExperimental physiology2026
Physical exercise intervention in glycogen storage disease IIIa: Feasibility and multisystem benefits.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Cardiopulmonary and skeletal muscle strategies underlying exhaustive exercise in adults with glycogen storage disease type III.Physiological reports · 2026Article
- An exercise intervention in children and young adults with McArdle disease: feasibility, acceptability, and clinical outcomes.Orphanet journal of rare diseases · 2026Article
- Physical exercise intervention in glycogen storage disease IIIa: Feasibility and multisystem benefits.Experimental physiology · 2026Article
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Authors and funding
15 authors.
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Abstract
Glycogen storage disease III (GSD-III) is caused by an inherited deficiency of the glycogen debranching enzyme. Affecting the liver, muscle and heart, GSD-IIIa is the most common GSD-III subtype. We evaluated the feasibility and safety of a physical exercise intervention in patients with GSD-IIIa and its effects at the multisystem level. Nine patients (four female; five children and four adults; 60% of all diagnosed Spanish patients) participated in a 12 week home-based, remotely supervised programme combining moderate-intensity endurance and resistance exercises. Training tolerance/adaptation (fatigue severity scale, wellbeing questionnaire) and safety were assessed throughout the intervention period. The following outcomes were determined at baseline and postintervention: Health-related quality of life; muscle, liver, kidney and cardiac damage/function biomarkers; dual X-ray absorptiometry-determined fat/muscle/bone mass; echocardiography-determined cardiac dimensions and left ventricular global longitudinal strain; endurance capacity indicators during cardiopulmonary exercise testing; and muscle strength. The patients completed a median of 88% (interquartile range, 87%-100%) of the prescribed sessions. The intervention was safe and well tolerated, with no changes in wellbeing over time and with a decrease in perceived fatigue severity during the intervention (p = 0.002). Barring alanine aminotransferase, there were no changes in blood biomarkers, and the following significant effects were found at postintervention: Decrease in visceral adipose tissue (p = 0.038); healthier cardiac geometry [from concentric to normal remodelling, with decreases in relative (p = 0.015) and posterior (p = 0.042) wall thickness]; and increases in peak oxygen uptake (p = 0.033), peak power output (p = 0.017) and knee-extension isometric strength (p = 0.012). Although more research is needed, the present findings suggest that exercise should be considered in GSD-IIIa management.
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