Evidence map›Paper›PMID 40448658›Full record

ReviewJournal of veterinary internal medicine

Immunosenescence and Inflammaging in Dogs and Cats: A Narrative Review.

Brennen A McKenzie

Abstract readReview
In one paragraph

Review in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Reference Intervals for Hematological Inflammatory Ratios in Healthy Dogs.Animals : an open access journal from MDPI · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Brennen A McKenzieLoyal-Veterinary Medicine, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-4097-8479

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A consistent and important feature of biological aging is the change in the types and functions of cells comprising the immune system. Across various mammalian species, this change follows consistent patterns, including diminished protective capacity, leading to increased vulnerability to infectious disease, and increased low-grade chronic inflammation, raising the risk of numerous aging-associated diseases. Although these patterns are well characterized in rodents and humans, there is less evidence available in companion animal species. The most recent review of the literature evaluating aging changes in the immune system in dogs and cats was published in 2010. The purpose of this narrative review is to summarize the currently available information concerning immune system aging in these species and to review what is known about the clinical consequences of this process and about potential strategies for mitigation.

Indexed as

AgingCat DiseasesDog DiseasesImmunosenescenceInflammationAnimalsCatsDogsaginggeroscienceimmune functionvaccine response

Identifiers

PMID40448658
PMCPMC12125923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.