ArticleNeurorehabilitation and neural repair2025
Trial-By-Trial Variation In Upper Extremity Movement Smoothness After Acute Stroke Relates To Clinical Assessments And Corticospinal Tract Injury.
Article in Neurorehabilitation and neural repair, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- A Comparison of Machine Learning Approaches to Activity Classification Using IMU Data Collected in a Community-Based Setting.Sensors (Basel, Switzerland) · 2026Article
- Stem Cells in Post-Stroke Regenerative Therapy: Current Role of Wharton's Jelly Mesenchymal Stem Cells in the Orchestrum.Brain sciences · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
BackgroundVariability in movement is critical for performance under dynamic conditions. Stroke causes focal injury to the motor system, disrupts voluntary motor control, and leads to less smooth and more variable upper extremity movements. Few studies have characterized trial-by-trial variation in upper extremity movement smoothness and its clinical and neuroanatomic correlates in the first week post-stroke.ObjectiveTo evaluate trial-by-trial variation in upper extremity movement smoothness during planar reaching and relate it to clinical outcomes and neuroanatomical injury after acute stroke.MethodsTwenty-two patients (4.4 ± 1.7 days post-stroke) and 22 able-bodied adults completed a planar center-out reaching task. Smoothness was quantified with spectral arc length (SPARC). Median and interquartile range (IQR, a quantification of trial-by-trial variation) of SPARC values were assessed. Patients completed a clinical assessment battery acutely and at 90 days post-stroke. MRI-derived stroke lesions were analyzed to estimate basal ganglia, motor cortex, and corticospinal tract injury. Intraclass correlation, Spearman's correlation, and multivariate regression evaluated trial-by-trial variation and its relation to clinical assessments, outcomes, and neuroanatomical injury.ResultsPost-stroke reaching was less smooth and more variable (larger IQR) compared to able-bodied adults. Variability in post-stroke smoothness was primarily driven by within-subject, trial-by-trial variation. More variable smoothness, even after controlling for median smoothness, related to worse performance on clinical assessments and 90-day outcomes. More variable smoothness related to greater corticospinal tract injury (ρ = 0.537,
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