ArticlePest management science2025
Detection of Vkorc1 single nucleotide polymorphisms indicates the presence of anticoagulant rodenticide resistance in Australia's introduced rats
Article in Pest management science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Distribution and frequency of Vkorc1 polymorphisms in house mice and Norway rats in the northeastern United States.Pest management science · 2026Article
- Impacts of rodents in piggeries in Australia - review and pilot impact study.Pest management science · 2026Review
- The Cat Is Already Out of the Bag: Humane and Pragmatic Solutions for Cats on Dairy Farms. Reply to Calver et al. It's Premature to Encourage Working Cats for Rodent Control on Australian Dairy Farms.Animals : an open access journal from MDPI · 2026Article
- A new nuclear marker, the "VKORC1 gene exon 3 region", for the identification of Anatolian Rattus spp.BMC zoology · 2025Article
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4 authors.
Funding
Abstract
backgroundAnticoagulant rodenticides (ARs) are used globally to manage pest rodent populations. However, resistance to ARs in target rodent populations challenges pest control efforts and can increase risks to nontarget species. Resistance is frequently associated with nonsynonymous single nucleotide polymorphisms (nsSNPs) in the Vkorc1 gene, and this study carried out the first Vkorc1 survey of introduced rats on the Australian mainland.
resultsWe identified three species of introduced rat using the cytochrome b gene across Brisbane, Melbourne, Perth and Sydney: Rattus rattus (Linnaeus 1758) (Lineage I); Rattus norvegicus (Berkenhout 1769); and Rattus tanezumi (Temminck 1844) (Lineage II). Three nsSNPs were detected in the Vkorc1 gene: Tyr25Phe, Trp59Arg and Phe55Ile. The mutation Tyr25Phe, which is associated with resistance to ARs, was identified in 58 of 108 R. rattus (53.7%) and one of 31 R. tanezumi (3.2%). It has been suggested that the mutation Trp59Arg (detected in two R. rattus) can increase susceptibility to haemorrhage, whereas the mutation Phe55Ile (identified in only one R. rattus) has not been reported previously. No nsSNPs were identified in R. norvegicus.
conclusionThis is the first update to the resistance status of introduced rats on the Australian mainland since the 1970s and the first to employ genetic screening. The widespread occurrence of Tyr25Phe in urbanized areas of Australia suggests potential resistance to ARs is common in R. rattus. However, practical resistance conferred by Tyr25Phe needs further investigation as does the role of hybridization in the transfer of resistance from the R. rattus to the R. tanezumi nuclear genome. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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